›› 2011, Vol. 31 ›› Issue (8): 1194-.doi: 10.3969/j.issn.1674-8115.2011.08.032

• Review • Previous Articles     Next Articles

Research progress of G protein-coupled receptor kinases in pathogenesis of Parkinson's disease

WU Na, LIU Zhen-guo   

  1. Department of Neurology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2011-08-28 Published:2011-08-29
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 0952nm03700, 09JC1411000；Shanghai Education Committee Foundation, 10ZZ72；Shanghai Baiyulan Science and Technology Talent Foundation,1009B097；National Natural Science Foundation of China, 81071025

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Abstract:

G protein-coupled receptor kinases (GRKs) are a class of important soluble proteins that mediate receptor desensitization. They are the essential elements in negative feedback mechanism of G protein-coupled receptors (GPCRs) signaling pathway. Increased neurohormonal levels in nervous system diseases and adverse consequences in nervous system diseases induced by sustained neurohormonal stimulation indicate that the desensitization of neural receptors is a very important protection mechanism. Recent researches have revealed that GRKs play an important role in the development of Parkinson's disease and its motor complications. GRK6, which is localized in mediumsized spinous neurons, is the most critical GRKs in striatum. GRK6 knockout is related to the hypersensitivity of dopamine receptor. The research progress of GRKs in the pathogenesis of Parkinson's disease is reviewed in this paper.

Key words: Parkinson´s disease, G protein-coupled receptor kinases, G protein-coupled receptor