Abstract:

Objective To investigate the expression of multidrug resistance protein P170 in newly diagnosed childhood acute leukemia, explore the relationship between the expression of P170 and multidrug resistance and its clinical significance. Methods Sixty-six cases of childhood acute leukemia were collected, among whom 40 were male and 26 were female. Forty-five cases were acute lymphoblastic leukemia (ALL) and 21 cases were acute non-lymphocytic leukemia (ANLL). Patients were divided into complete remission group (n=40) and relapse group (n=26). The expression of multidrug resistance protein P170 in marrow cells was detected by flow cytometry, and the correlations of the expression of P170 with drug resistance and gender were analysed. Results The expression of P170 in relapse group was significantly higher than that in complete remission group (65.4% vs 37.5%, P<0.05), while there was no significant difference in the expression of P170 between ANLL group and ALL group (44.4% vs 57.1%, P>0.05) and between male group and female group (45.0% vs 46.2%，P>0.05). Conclusion The expression of P170 in newly diagnosed childhood acute leukemia is likely to result in multidrug resistance and negative prognosis. There is no significant difference in the expression of P170 between different disease types and different genders in childhood acute leukemia.

Key words: childhood acute leukemia, multidrug resistance, P170