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Progress in applications of anti-senescence materials for tissue repair
Received date: 2025-02-24
Accepted date: 2025-07-06
Online published: 2025-12-03
Supported by
National Natural Science Foundation of China(82425035);The 19th Innovative Training Program for College Students of Shanghai Jiao Tong University School of Medicine(19250008)
Tissue repair is an important physiological process after tissue injury, but it is often disrupted by tissue fibrosis, oxidative stress, and other problems, accompanied by cellular senescence. Cellular senescence refers to the proliferation stagnation and function decline of cells under adverse stimuli, which plays a bidirectional regulatory role in tissue repair. In the early stage of wound healing, it can limit fibrosis and induce cell plasticity, thus promoting repair. Nevertheless, the long-term accumulation of senescent cells will interfere with the normal proliferation and differentiation of cells and hinder the repair process. In recent years, with the development of histology and cell biology, the mechanisms of tissue repair and cellular senescence have been deeply studied, providing a theoretical basis for the application of anti-senescence materials to tissue repair. Ingredients in anti-senescence materials, such as anti-senescence drugs, energy supplements, and antioxidants, play a favorable role by inducing apoptosis, activating autophagy, reversing the senescence process, and other mechanisms. The application of these anti-senescence materials provides new ideas to solve clinical problems like tissue fibrosis in chronic wounds, and is expected to become an effective means to intervene in tissue regeneration. In recent years, anti-senescence materials have been widely used in tissue regeneration and repair. This review may promote the translation and application of more fundamental research and provide references for clinical tissue repair.
HOU Senlin , DENG Xiangtian , ZHENG Tingjia , HAN Yifei , LIU Shen . Progress in applications of anti-senescence materials for tissue repair[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025 , 45(11) : 1527 -1535 . DOI: 10.3969/j.issn.1674-8115.2025.11.012
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