Journal of Shanghai Jiao Tong University (Medical Science) >
Mechanism and therapeutic strategies of myocardial infarction based on circadian rhythm genes
Received date: 2025-06-26
Accepted date: 2025-09-03
Online published: 2025-12-22
Supported by
National Natural Science Foundation of China(82325005)
The circadian rhythm of mammals spans approximately 24 h and is of great significance in maintaining life activities and contributing to the occurrence and progression of various diseases. This intrinsic rhythm is primarily regulated by transcription-translation feedback loops (TTFLs) mediated by core circadian molecules. Circadian genes participate in cardiovascular disease by regulating metabolism, oxidative stress, and inflammatory responses, and play a key role in myocardial infarction. In recent years, with advances in circadian gene research, the underlying molecular mechanisms in myocardial infarction have become increasingly elucidated. This review summarizes the specific molecular mechanisms and clinical research evidence related to core circadian molecules (such as BMAL1, CLOCK, PER, and CRY) in the context of myocardial infarction, explores the therapeutic potential of circadian genes, and discusses current research challenges and future directions in this field. These findings indicate that targeting circadian genes may have promising clinical applications, and could provide new strategies for the treatment of myocardial infarction.
Key words： circadian rhythm genes; myocardial infarction; molecular clock
HUANG Mingwang , JIA Kangni , YAN Xiaoxiang . Mechanism and therapeutic strategies of myocardial infarction based on circadian rhythm genes[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025 , 45(12) : 1671 -1678 . DOI: 10.3969/j.issn.1674-8115.2025.12.013
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