›› 2010, Vol. 30 ›› Issue (6): 612-.

• Monographic report (Depressive disorder) • Previous Articles     Next Articles

Association of tryptophan hydroxylase 2 gene polymorphisms with major depression disorder and antidepressant treatment response

CAO Lan, FANG Yi-ru, YU Shun-ying, HU Ying-yan, Hong Wu, ZHANG Chen, YI Zheng-hui, YUAN Cheng-mei, CHEN Jun, WU Zhi-guo, LI Ze-zhi, HUANG Jia   

  1. Division of Mood Disorder, Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China
  • Online:2010-06-25 Published:2010-06-28
  • Supported by:

    National Key Technologies R&D Program of “10th Five-Year Plan”， 2004BA720A21-02；Hi-Tech Research and Development Program of China, “863” Program，2006AA02Z430；Shanghai “Climbing Mountain Action Plan” Program, 064119533

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Abstract:

Objective To investigate the association of tryptophan hydroxylase 2 (TPH-2) gene single nucleotide polymorphisms (SNPs) of loci rs4570625 and rs7305115 with major depression disorder (MDD) and antidepressant treatment response in Chinese Han populations. Methods A total of 346 Chinese Han patients with MDD (case group) and 347 healthy Chinese Han people (control group) were enrolled, and patients in case group were subdivided into treatment-resistant depression (TRD) group (n=72) and non-TRD (NTRD) group (n=274) according to treatment response. SNPs of rs4570625 and rs7305115 were selected for the genomic region of TPH-2 gene and genotyped through TaqMan SNP genotyping assay, and the distribution of gene type and allele in groups was analysed. Results There were significant differences in distribution of rs4570625 gene type and allele between case group and control group (P<0.05). There were significant differences in distribution of SNPs rs4570625 and rs7305115 gene type and allele between males of TRD group and males of NTRD group (P<0.05). Conclusion TPH-2 gene rs4570625 may be associated with depression disorder in Chinese Han populations, and SNPs of rs4570625 and rs7305115 may predict the antidepressant treatment response in male patients.

Key words: major depression disorder, treatment response, tryptophan hydroxylase 2, gene