上海交通大学学报（医学版）

上海交通大学学报（医学版）

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LncRNA分子生物学属性及其在中枢神经系统发育中的调控作用

徐楚帆，江来   

  1. 上海交通大学 医学院附属新华医院麻醉与重症医学科，上海 200092
  • 出版日期:2017-02-28 发布日期:2017-02-28
  • 通讯作者: 江来，电子信箱：jianglaimz@sina.com。
  • 作者简介:徐楚帆（1991—），女，硕士生；电子信箱：xuchufan@sjtu.edu.cn。
  • 基金资助:

    新华医院千天计划项目（15QT01）

Molecular biological properties of lncRNA and their regulatory functions in the development of central nervous system

XU Chu-fan, JIANG Lai   

  1. Department of Anesthesia and Intensive Care Unit, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2017-02-28 Published:2017-02-28
  • Supported by:

    Xin Hua Early Life Plan，15QT01

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摘要：

长非编码RNA（lncRNA）是指长度＞200个核苷酸的非编码RNA，以RNA形式直接发挥作用。它们的功能受其二级结构、转录后修饰等因素的影响。LncRNA种类繁多，作用机制复杂。在人类诱导多能干细胞（iPSCs）及胚胎干细胞（ESCs）的神经分化过程中，人们已监测到多种lncRNA的动态表达，并发现了一系列对中枢神经系统发育过程有重要调控作用的lncRNA。该文就lncRNA的分子生物学属性及目前已发现的lncRNA在中枢神经系统发育中的调控作用进行归纳总结。这将有利于揭示神经系统疾病发生发展的机制，并为其诊治开辟新思路。

关键词: lncRNA, 分子生物学属性, 中枢神经系统发育, 调控作用

Abstract:

Long noncoding RNA (lncRNA) refers to RNA transcripts with more than 200 nucleotides in length, which plays regulatory roles directly in the form of RNA. Their functions are affected by their secondary structures, post transcriptional modification and so on. LncRNA can be classified to various subtypes with complicated mechanisms. In human-induced-pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), dynamic expression of some lncRNAs is detected during the neuronal differentiation, and a series of lncRNAs associated closely with the development process of the central nervous system (CNS) are found. This review summarizes the molecular biological properties of lncRNA and their regulatory functions in the development of the CNS, which is helpful to reveal the mechanisms of the pathogenesis and progression of certain neurological diseases and results in innovation of their diagnosis and treatment.

Key words: lncRNA, molecular biological property, development of central neuronal system, regulatory function