上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (1): 124-.doi: 10.3969/j.issn.1674-8115.2012.01.026

• 短篇论著 • 上一篇    下一篇

异丙酚和硫喷妥钠对内源信号视觉光学成像强度的影响比较

任荣荣, 赵 璇   

  1. 上海交通大学 医学院附属新华医院麻醉科, 上海 200092
  • 出版日期:2012-01-28 发布日期:2012-01-29
  • 作者简介:任荣荣（1981—）, 女, 住院医师, 硕士；电子信箱: ren_rongrong@yahoo.cn。
  • 基金资助:

    上海市科委科研计划项目（09140900902）

Comparison of effects of propofol and thiopental sodium on intrinsic optical imaging intensity

REN Rong-rong, ZHAO Xuan   

  1. Department of Anesthesiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2012-01-28 Published:2012-01-29
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 09140900902

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摘要：

目的 探讨异丙酚和硫喷妥钠对猕猴内源信号视觉光学成像强度的影响。方法 6只猕猴分为硫喷妥钠组和异丙酚组，每组3只。15 mg/kg氯胺酮肌肉注射麻醉诱导，硫喷妥钠组以1.5 mg/(kg·h)硫喷妥钠、0.15 mg/(kg·h)维库溴铵、1%～2%异氟醚、0.5～2 L/min氧化亚氮和1～2 L/min氧气维持麻醉，异丙酚组以5 mg/(kg·h)异丙酚、0.15 mg/(kg·h)维库溴铵、1%～2%异氟醚、0.5～2 L/min氧化亚氮和1～2 L/min氧气维持麻醉，监测各猕猴的生命体征;给予猕猴正弦光栅视觉信号刺激，刺激方向为0°和90°，收集猕猴视觉皮层图像信号，分析图像反应区平均强度。结果 两组猕猴心率、血氧饱和度、呼气末二氧化碳分压、体温及图像反应区平均强度差异均无统计学意义（P>0.05）。结论 硫喷妥钠与异丙酚内源信号光学成像强度无显著差异。

关键词: 猕猴, 内源性光学成像, 异丙酚, 硫喷妥钠

Abstract:

Objective To investigate the effects of propofol and thiopental sodium on intrinsic optical imaging intensity of macaques. Methods Six macaques were divided into propofol group and  thiopental sodium group, with 3 macaques in each group. Intramuscular injection of 15 mg/(kg·h) ketamine was performed for anesthesia induction in two groups, and 1.5 mg/(kg·h) thiopental sodium, 0.15 mg/(kg·h) vecuronium, 1%-2% isoflurane, 0.5-2 L/min nitroxide and 1-2 L/min oxygen were used to maintain anesthesia in thiopental sodium group, while 5 mg/(kg·h) propofol, 0.15 mg/(kg·h) vecuronium, 1%-2% isoflurane, 0.5-2 L/min nitroxide and 1-2 L/min oxygen were used to maintain anesthesia in propofol group, and  the vital signs of macaques were recorded. Macaques in two groups were treated with visual stimulus of sinusoidal grating, with the direction of 0° and 90°, visual cortex imaging signals of macaques were detected, and mean imaging intensity was calculated. Results There was no significant difference in heart rates, oxygen saturation, end-tidal carbon dioxide partial pressure, temperature and mean imaging intensity between two groups (P>0.05). Conclusion There is no significant difference in intrinsic optical imaging intensity between thiopental sodium and propofol.

Key words: macaque, intrinsic optical imaging, propofol, thiopental sodium