上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (1): 96-.doi: 10.3969/j.issn.1674-8115.2012.01.020

• 论著（卫生事业管理） • 上一篇    下一篇

血清总胆固醇与高密度脂蛋白胆固醇比值对重庆市中青年人群高血压的预测价值

邱 蕾, 钟晓妮, 宋文丰, 田考聪   

  1. 重庆医科大学 |公共卫生学院卫生统计教研室, 重庆 400016
  • 出版日期:2012-01-28 发布日期:2012-01-29
  • 通讯作者: 田考聪, 电子信箱: tkc5155@126.com。
  • 作者简介:邱 蕾（1988—）, 女, 硕士生；电子信箱: qiulei2010@sina.com。

Role of total cholesterol to high-density lipoprotein-cholesterol ratio in prediction of hypertension in mid-aged and young people in Chongqing

QIU Lei, ZHONG Xiao-ni, SONG Wen-feng, TIAN Kao-cong   

  1. Department of Biostatistics, School of Public Health, Chongqing Medical University, Chongqing 400016, China
  • Online:2012-01-28 Published:2012-01-29

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摘要：

目的 探讨不同血脂指标对重庆市中青年人群高血压的预测价值。方法 采集2009年在重庆医科大学附属第一医院体检中心体检的20 000例数据，分析三酰甘油（TG）、血清总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）以及非高密度脂蛋白胆固醇（Non-HDL-C）与血压（收缩压/舒张压，SBP/DBP）的相关性以及各项血脂指标之间的相关性；再选择与血压相关性较强的血脂指标，分析这些指标及其不同组合在预测高血压受试者工作特征曲线（ROC）的曲线下面积中的价值。结果 体检结果显示高血压患者3 102例（总患病率为15.51%），其中男性2 294例，女性808例；男性患病率高于女性，差异有统计学意义（20.43%和9.21%，P<0.05）。调整高血压患者的年龄和性别后，TC/HDL-C与血压的相关性最强，其次为LDL-C/HDL-C和Non-HDL-C；TC/HDL-C与LDL-C/HDL-C、Non-HDL-C、HDL-C、TG及LDL-C均呈强相关（r分别为0.926、0.784、-0.753、0.724及0.715），与TC也呈正相关（r=0.642），均P<0.001。TC/HDL-C、LDL-C/HDL-C、Non-HDL-C、TG及其不同组合预测的高血压ROC曲线下面积均>0.5，其中TC/HDL-C预测的ROC曲线下面积最大；对于同一项血脂指标或其组合的预测结果显示，女性高血压患者的ROC曲线下面积均大于男性患者，差异具有统计学意义（P<0.05）。结论 TC/HDL-C可能是预测高血压的最佳血脂指标，尤其能反映高血脂对重庆市中青年女性高血压的影响。

关键词: 高血压, 血脂指标, 胆固醇/高密度脂蛋白, ROC曲线

Abstract:

Objective To investigate the role of different serum lipid parameters in prediction of hypertension in mid-aged and young people in Chongqing. Methods The data of 20 000 subjects undergoing health examinations in Health Examination Center of the First Affiliated Hospital of Chongqing Medical University in 2009 were collected. The correlation of triglyceride (TG), serum total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) and non-high-density lipoprotein-cholesterol (Non-HDL-C) with systolic blood pressure (SBP) and diastolic blood pressure (DBP) was explored, and the relationship among different serum lipid parameters were analysed. Serum lipid parameters with strong correlation with blood pressure were selected, and role of these parameters and their different combinations in prediction of area under receiver operator characteristic (ROC) curve of subjects with hypertension was analysed. Results Health examinations revealed that three were 3 102 patients with hypertension, and the prevalence was 15.51%. Among these patients, there were 2 294 males and 808 females, and the prevalence of males was significantly higher than that of females (20.43% vs 9.21%，P<0.05). After adjustment for age and sex of patients with hypertension, TC/HDL-C had the strongest correlation with blood pressure, followed by LDL-C/HDL-C and Non-HDL-C. TC/HDL-C had strong correlation with LDL-C/HDL-C, Non-HDL-C, HDL-C, TG, LDL-C and TC (r=0.926, 0.784, -0.753, 0.724, 0.715 and 0.642 respectively; P<0.001 for all). All the areas under ROC curve of hypertension predicted by TC/HDL-C, LDL-C/HDL-C, Non-HDL-C, TG and their different combinations were >0.5, and the area under ROC curve predicted by TC/HDL-C was the largest. For the same serum lipid parameter and its combinations, areas under ROC curve of females were significantly larger than those of males (P<0.05). Conclusion C/HDL-C may be the optimal serum lipid parameter in prediction of hypertension in Chongqing mid-aged and young people, especially for females.

Key words: hypertension, serum lipid parameter, total cholesterol to high-density lipoprotein-cholesterol ratio, ROC curve