上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

选择性激光小梁成形术联合药物治疗在开角型青光眼中的应用

谭海波1,2,祝丽娜1,2,沈洁1,2   

  1. 上海交通大学 医学院 1.附属仁济医院南院眼科， 上海 201112； 2.附属仁济医院眼科, 上海 200127
  • 出版日期:2015-12-28 发布日期:2016-01-21
  • 通讯作者: 沈洁, 电子信箱: shenjie@renji.com。
  • 作者简介:谭海波（1976—）， 男， 主治医师， 博士; 电子信箱: tnada@126.com。

Application of selective laser trabeculoplasty combined with medication to the treatment of open-angle glaucoma

TAN Hai-Bo1,2, ZHU Li-na1,2, SHEN Jie1,2   

  1. 1.Department of Ophthalmology, Renji Hospital South Campus, Shanghai Jiao Tong University School of Medicine, Shanghai 201112, China； 2.Department of Ophthalmology, Renji Hospital， Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2015-12-28 Published:2016-01-21

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摘要：

目的  观察选择性激光小梁成形术(SLT)联合抗青光眼滴眼液与单用药物治疗在降低原发性开角型青光眼或高眼压症患者眼压以及减少药物种类中的作用。方法  选择药物治疗达到目标眼压的原发性开角型青光眼或高眼压症患者78例156只眼。SLT联合药物组（39例78只眼）行360°SLT联合药物治疗；单用药物组（39例78只眼）仅用药物治疗；2组依据眼压水平调整用药。结果  治疗前,SLT联合药物组和单用药物组眼压及用药种类的差异均无统计学意义（P>0.05）。治疗6个月时，SLT联合药物组眼压[（17.73±3.40）mmHg]低于单用药物组[（19.89±2.90）mmHg],差异有统计学意义（P<0.05）；SLT联合药物组治疗后的眼压低于治疗前（P<0.001）。治疗6个月时，SLT联合药物组用药种类[（2.19±0.30）种]少于单用药物组[（3.22±0.40）种]，差异有统计学意义（P<0.001）；SLT联合药物组治疗后的用药种类少于治疗前（P<0.001）。结论  SLT联合药物治疗能进一步降低眼压，并减少使用的抗青光眼药物种类。

关键词: 选择性激光小梁成形术, 眼压, 抗青光眼药物

Abstract:

Objective  To investigate the effects of selective laser trabeculoplasty (SLT) combined with anti-glaucoma eye drops and medication alone on decreasing the intraocular pressure (IOP) of patients with primary open-angle glaucoma or ocular hypertension and types of medication. Methods  A total of 78 patients (156 eyes) of primary open-angle glaucoma or ocular hypertension whose IOPs met the target IOP after medication were selected. The SLT combined with medication group (39 patients, 78eyes) underwent 360° SLT combined with medication and medication alone group only underwent medication. Both groups adjusted the medication according to the IOP. Results  The differences of IOP and types of medication between SLT combined with medication group and medication alone group before treatment were not statistically significant (P>0.05). After 6 months of treatment, IOP of SLT combined with medication group (17.73±3.40) mmHg were lower than those of medication alone group (19.89±2.90) mmHg and the difference was statistically significant (P<0.05). IOP of SLT combined with medication group after treatment were lower than those before treatment (P<0.001). After 6 months of treatment, types of medication of SLT combined with medication group (2.19±0.30) were less than those of medication alone group (3.22±0.40) and the difference was statistically significant (P<0.001). Types of medication of SLT combined with medication group after treatment were less than those before treatment (P<0.001). Conclusion  SLT combined with medication can further decrease the IOP and types of anti-glaucoma medication.

Key words: selective laser trabeculoplasty, intraocular pressure, anti-glaucoma medication