上海交通大学学报（医学版）

上海交通大学学报（医学版）

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miR-146a影响胃癌进程的分子机制研究进展

吴强强1，祖立冬2   

  1. 上海交通大学 1.医学院，2.基础医学院病理学系，上海 200025
  • 出版日期:2016-11-28 发布日期:2016-11-29
  • 通讯作者: 祖立冬，电子信箱：zulidong@163.com。
  • 作者简介:吴强强（1992—），男，硕士生；电子信箱：Wqqmorry@163.com。

Research advances on the molecular mechanism of influencing the progression of gastric cancer by miR-146a

WU Qiang-qiang 1, ZU Li-dong2   

  1. 1. Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2. Department of Pathology, Basic Medicine Faculty, Shanghai Jiao Tong University, Shanghai 200025, China
  • Online:2016-11-28 Published:2016-11-29

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摘要：

胃癌是全世界主要的恶性肿瘤。目前，研究表明miR-146a作为一种抑癌基因，能够促进mRNA的降解或抑制其蛋白合成，从而维持细胞内正常生理代谢功能。但miR-146a在胃癌的发展过程中表达量下降，导致细胞内多种信号通路失去正常调控，从而促进肿瘤的增殖及转移；但miR-146a影响胃癌进程的分子机制仍不清楚。文章对miR-146a在胃癌进程中的分子机制研究进展及临床应用作一综述。

关键词: 胃癌, miR-146a, 转移, 抑癌基因, 分子机制

Abstract:

Gastric cancer is a major malignant tumor worldwide. Currently, lots of researches confirm that as a cancer suppressor gene, miR-146a can promote the degradation of mRNA and inhabit the synthesis of proteins, so as to maintain normal physiological metabolism function in cells. But the expression of miR-146a decreases in the progression of gastric cancer, resulting in losing normal control for many signaling pathways in cells and promoting the proliferation and metastasis of cancer cells. The molecular mechanism of influencing the progression of gastric cancer by miR-146a is still unclear. This paper reviews research advances on this topic and relevant clinical applications.

Key words: gastric cancer, miR-146a, metastasis, cancer suppressor gene, mechanism