上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (12): 1699-.doi: 10.3969/j.issn.1674-8115.2017.12.023

• 综述 • 上一篇    下一篇

噬菌体多糖解聚酶及其应用

李晓倩 1，王睿 1，顾川佳 1，徐梦莎 1, 2，何平 1，胡付品 3   

  1. 1. 上海交通大学基础医学院病原生物学教研室，上海 200025；2. 浙江工业大学药学院，杭州 310014；3.复旦大学附属华山医院抗生素研究所，上海 200040
  • 出版日期:2017-12-28 发布日期:2018-01-10
  • 通讯作者: 何 平，电子信箱：hpatsh@sjtu.edu.cn。
  • 作者简介:李晓倩（1995—），女，本科生；电子信箱：xiaoqian825850505@qq.com
  • 基金资助:
     国家自然科学基金（81471908）

Introduction and applications of bacteriophage polysaccaride depolymerases

LI Xiao-qian1, WANG Rui1, GU Chuan-jia1, XU Meng-sha1, 2, HE Ping1, HU Fu-pin3   

  1. 1. Department of Medical Microbiology and Parasitology, Basic Medicine Faculty of Shanghai Jiao Tong University, Shanghai 200025, China; 2. College of Pharmacy of
    Zhejiang University of Technology, Hangzhou 310014, China; 3. Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Online:2017-12-28 Published:2018-01-10
  • Supported by:
    National Natural Science Foundation of China, 81471908

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摘要： [ 摘要 ] 随着临床上广泛耐药菌株的检出率逐年升高，新型抗菌药物需求日益迫切。越来越多的研究者们将注意力集中到噬菌体治疗上，并在这个领域取得了较大的进展。大量的研究表明，一些噬菌体能够产生降解细菌胞外聚合物基质的多糖解聚酶，继而裂解并杀死宿主菌。该文综述了噬菌体多糖解聚酶的分类和作用方式，判断噬菌体是否产生解聚酶的方法，以及该酶在治疗细菌性感染、降解生物膜和细菌荚膜分型上的应用。

关键词: &ensp, 噬菌体；多糖解聚酶；生物膜；细菌性感染

Abstract:

[Abstract] With the rising detection rate of strains with extensive drug resistance clinically, there is an increasingly urgent need of novel anti-microbial
agents. More and more researchers put emphasis on bacteriophage therapy and have made great progress in this field. A large number of studies showed
that some bacteriophages could produce enzymes which killed the host bacteria by degrading polysaccharides in their extracellular polymeric substances
(EPS). This review introduces the classification of phage polysaccharide depolymerases and their action mode, the methods to determine whether the
phage produces depolymerases, and their applications in anti-bacterial treatment, biofilm degradation and bacterial capsule typing.

Key words: bacteriophage, polysaccharide depolymerase, biofilm, bacterial infection