上海交通大学学报（医学版）

上海交通大学学报（医学版）

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二膦酸盐类药物的抗肿瘤作用

靳丽丽，孙晓光，黄 钢   

  1. 上海交通大学 医学院附属仁济医院核医学科， 上海 200127
  • 出版日期:2013-09-28 发布日期:2013-09-29
  • 作者简介:靳丽丽（1986—）， 女， 硕士生; 电子信箱: liliedm@163.com。

Anti-tumor effect of bisphosphonate drugs

JIN Li-li, SUN Xiao-guang, HUANG Gang   

  1. Department of Nuclear Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2013-09-28 Published:2013-09-29

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摘要：

二膦酸盐类药物自从被发现具有抑制破骨细胞作用以来，已成为临床上重要的抗骨吸收药物。近年来发现，二膦酸盐类药物也可作用于肿瘤细胞，具有抗肿瘤作用。尤其是与其他抗肿瘤药物的协同作用，使其在临床上能更好地发挥抗肿瘤作用，改善患者的生活质量。该文主要对二膦酸盐类药物的抗肿瘤作用进行综述。

关键词: 二膦酸盐类药物, 抗肿瘤, 协同作用

Abstract:

Bisphosphonate drugs have become important drugs for anti-resorption of bone in clinics since they were found to have inhibitory effect on osteoclasts. Recently, more and more researches propose that bisphosphonate drugs can also affect tumor cells, exhibiting the anti-tumor activity. Especially, the synergy effect of bisphosphonate drugs and anti-tumor drugs makes bisphosphonate drugs play a better anti-tumor role in clinics, improving the quality of life of patients. This paper reviews the anti-tumor effect of bisphosphonate drugs.

Key words: bisphosphonate drugs, anti-tumor, synergy effect