上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (5): 578-.doi: 10.3969/j.issn.1674-8115.2018.05.020

• 综述 • 上一篇    下一篇

吴茱萸碱抗肿瘤机制的研究进展

徐俊杰 1，杨然 1，杨芳景 1，焦鑫 1，刘颖斌 2   

  1. 1. 上海交通大学医学院，上海 200025；2. 上海交通大学医学院附属新华医院普外科，上海 200092
  • 出版日期:2018-05-28 发布日期:2018-05-28
  • 通讯作者: 刘颖斌，电子信箱：liuybphd@126.com。
  • 作者简介:徐俊杰（1995—），男，本科生；电子信箱： shjdxjj@163.com。
  • 基金资助:
    国家自然科学基金（81272402）；上海交通大学医学院“大学生创新训练项目”第 10期（2016089）

Recent advances in the antitumor effects of evodiamine

XU Jun-jie1, YANG Ran1, YANG Fang-jing1, JIAO Xin1, LIU Ying-bin2   

  1. 1. Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2. Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2018-05-28 Published:2018-05-28
  • Supported by:
    National Natural Science Foundation of China, 81272402; The 10th Undergraduate Training Program for Innovation of Shanghai Jiao Tong University School of Medicine, 2016089

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摘要： 吴茱萸碱是从中药吴茱萸中提取的天然生物碱。除具有较强的抗炎、镇痛等作用外，吴茱萸碱还能抑制肿瘤细胞活性与增殖、阻滞细胞周期、促进凋亡、促进自噬、抑制肿瘤微血管形成以及影响肿瘤表观遗传学修饰等。相关的通路如 PI3K-Akt和 JAK-STAT通路以及其对生存素、血管内皮生长因子和 miRNA的作用也陆续被揭示。随着吴茱萸碱相关衍生物和中药制剂不断地被合成与改进，研究人员对其抗肿瘤活性的认识逐步深入，推测其在未来具有较大的临床和药用开发价值。

关键词: 吴茱萸碱, 抗肿瘤活性, 作用机制, 衍生物, 联合用药

Abstract:

Evodiamine is the natural component extracted Euodiae Fructus. Recently, growing evidence has proved that evodiamine has great effects on suppressing cell viability and proliferation, arresting cell cycle, inducing apoptosis, promoting autophagy, inhibiting the formation of microvascular angiogenesis as well as affecting epigenetic modification in cancer. Recent studies have continuously revealed related signal pathways involved in evodiamine such as PI3K-Akt and JAK-STAT pathways, as well as the impact of evodiamine on survivin, vascular endothelial growth factor and miRNAs. With the development and synthesis of evodiamine derivatives and related herbal formulations, the understanding of antitumor activity of evodiamine is gradually deepening. The important clinical significance and market value of evodiamine can be prospected.

Key words: evodiamine, antitumor activity, mechanism, derivative, combined medication

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