上海交通大学学报(医学版)

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石墨烯、石墨烯衍生物及其复合材料在组织工程中的应用进展

曹忆梦1,吴氢凯2   

  1. 1. 苏州大学医学部研究生管理办公室,苏州 215123;2. 上海交通大学附属第六人民医院妇产科,上海 200233
  • 出版日期:2017-01-28 发布日期:2017-01-19
  • 通讯作者: 吴氢凯,电子信箱:angelh2@163.com。
  • 作者简介:曹忆梦(1992—),女,硕士生,电子信箱:1046782898@qq.com。
  • 基金资助:

    国家自然科学基金(81550008)

Application progress of graphene, graphene derivatives and graphene composites in tissue engineering

CAO Yi-meng1, WU Qing-kai2   

  1. 1. Graduate Department, Medical college of Soochow University, Suzhou 215123, China; 2.Department of Obstetrics and Gynecology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2017-01-28 Published:2017-01-19
  • Supported by:

    National Natural Science Foundation of China, 81550008

摘要:

石墨烯是一种由碳原子以sp2杂化轨道组成的六角型平面多环芳香烃原子晶体。基于石墨烯的纳米材料具有卓越的理化性质,近年来在医疗应用领域的研究成为热点,可用在药物载体、基因传递、生物检测、肿瘤治疗、抗菌和组织工程等方面。该文综述了石墨烯材料的性能、制备方法和众多衍生物的特性,介绍了石墨烯类材料在组织工程方面的研究进展,包括在创伤愈合、干细胞工程、肌肉骨骼工程方向的应用,展望了石墨烯在组织工程领域未来的发展。

关键词: 石墨烯, 石墨烯衍生物, 石墨烯复合材料, 氧化石墨烯, 组织工程

Abstract:

Graphene is one of the crystalline forms of carbon, which is composed of a single monolayer of sp2 hybridized orbitals tightly packed to a two-dimensional honeycomb lattice. Because of its remarkable physiochemical properties, graphene based nanomaterials have become a hot research topic in the field of biological applications, which are available in drug delivery, gene delivery, biological detection, tumor treatment, antibacterial, tissue engineering, etc. This paper reviews the material properties, preparation methods and many derivatives of graphene, and introduces the research progress of graphene based materials in tissue engineering, including the application in wound healing, stem cell engineering, skeletal muscle engineering. The future development of graphene in the field of tissue engineering is prospected.

Key words: graphene, graphene derivatives, graphene composites, graphene oxide, tissue engineering