上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

中老年男性勃起功能与血清睾酮的相关性研究

梁国庆1，于晓华2*，吴 旻3，沈育忠2，李建辉2，郑俊彪2，王 峻2，李余敏2, 俞金峰2，李 冬2，李 铮3   

  1. 1.上海中医药大学附属市中医医院泌尿外科， 上海 200071； 2.浙江省嘉善县第一人民医院泌尿外科， 嘉善 314100； 3.上海交通大学 医学院附属仁济医院泌尿外科， 上海 200135
  • 出版日期:2014-02-28 发布日期:2014-03-25
  • 通讯作者: 李 铮, 电子信箱: lizhengboshi@163.com。
  • 作者简介:梁国庆（1977—）， 男， 主治医师， 硕士; 电子信箱: applessw@163.com; 于晓华（1964—）， 男， 副主任医师， 学士; 电子信箱: jsdoctoryu@gmail.com。*为共同第一作者。
  • 基金资助:

    上海市卫生局课题（20134392）；上海市科委重大科研基金（09DJ1400400）

Correlation between erectile function and serum testosterone in old and middle-aged males

LIANG Guo-qing1, YU Xiao-hua2*, WU Min3, SHEN Yu-zhong2, LI Jian-hui2, ZHENG Jun-biao2, WANG Jun2, LI Yu-min2, YU Jin-feng2, LI Dong2, LI Zheng3   

  1. 1.Department of Urology, Shanghai Hospital of Traditional Chinese Medicine, Shanghai Traditional Chinese Medicine University, Shanghai 200071, China; 2.Department of Urology, Jiashan No.1 People′s Hospital, Jiashan 314100, China; 3.Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China
  • Online:2014-02-28 Published:2014-03-25
  • Supported by:

    Shanghai Municipal Health Bureau Foundation, 20134392; Major Research Program of Science and Technology Commission of Shanghai Municipality, 09DJ1400400

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摘要：

目的 探讨中老年男性勃起功能（EF）与血清总睾酮（TT）、游离睾酮（FT）和生物活性睾酮（Bio-T）之间的相关关系。方法 采用问卷调查的方式，比较236例正常勃起人群,369例轻度勃起功能障碍（ED）和390例中、重度ED患者的勃起功能指数评分（IIEF），化学发光法（CLIA）检测TT和性激素结合球蛋白（SHBG），计算FT和Bio-T水平。结果 中老年男性人群的ED发病率为76.28%，随着增龄而显著升高。ED患者的TT水平略低于正常勃起人群，但差异无统计学意义(P>0.05)；而FT和Bio-T显著低于正常勃起人群，差异具有统计学意义(P<0.01)。TT在不同IIEF评分的ED患者之间没有变化规律，FT和Bio-T则随着IIEF评分的减低而明显下降。Pearson相关分析显示：TT与IIEF评分之间无相关性，FT和Bio-T与IIEF评分呈显著正相关(P<0.01)。结论 中老年男性ED发病率随增龄显著升高。TT水平与ED无明显相关关系，而FT和Bio-T与ED显著相关；FT和Bio-T内分泌诊断价值优于TT，更能准确反应ED患者的血清睾酮水平。

关键词: 中老年男性, 勃起功能, 总睾酮, 游离睾酮, 生物活性睾酮

Abstract:

Objective To study the relationship of erectile function (EF) and serum total testosterone (TT), free testosterone (FT), and bioavailable testosterone (Bio-T) of old and middle-aged males. Methods The International Index of Erectile Function questionnaires was used to evaluate 236 people with normal EF, 369 patients with mild erectile dysfunction (ED), and 390 patients with moderate and severe ED. The serum total testosterone (TT) and sex hormone-binding globulin (SHBG) were measured by chemilum inescentenzyme immunoassay (CLIA) method, and free testosterone (FT) and bioavailable testosterone (Bio-T) levels were calculated. Results The incidence of ED was 76.28% among old and middle-aged males and increased significantly with the age. The TT levels of ED patients were slightly lower than those of people with normal EF (P>0.05). While FT and Bio-T values were significantly lower than those of people with normal EF (P<0.01). The variations of TT among ED patients with different IIEF scores are not regular, while FT and Bio-T decreased significantly with decreasing of IIEF score. Pearson regression analysis revealed that TT was not related to IIEF score, while FT and Bio-T were significantly related to IIEF score (P<0.01). Conclusion The incidence of ED among old and middle-aged males increases significantly with the age. The TT level is not significantly related to ED, but FT and Bio-T are significantly related to ED. The endocrine diagnostic value of FT and Bio-T is better than TT and can reflect the serum testosterone level of ED patients more accurately.

Key words: old and middle-aged males, erectile function, total testosterone, free testosterone, bioavailable testosterone