上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

家族性高三酰甘油血症家系心脑血管终点事件观察

刘维娟1，何津春1,2，何津祥3，周珊珊1，朱槿宏2，杨永建4   

  1. 兰州大学 1.第一临床医学院， 2.第一医院医学检验中心， 3.第一医院放射治疗中心， 4.药学院， 兰州730000
  • 出版日期:2014-12-28 发布日期:2014-12-30
  • 作者简介:刘维娟（1987—）， 女， 硕士生; 电子信箱: liuweijuan40511@126.com。
  • 基金资助:

    国家“十五”重大科技专项(2002DA711A028-17)；教育部科技基础平台建设项目(505015)；甘肃省自然科学研究基金 (1308RJZA218)

Observation of cardiac and cerebral vascular endpoint events of families with familial hypertriglyceridemia

LIU Wei-juan1, HE Jin-chun1,2, HE Jin-xiang3, ZHOU Shan-shan1, ZHU Jin-hong2, YANG Yong-jian4   

  1. 1.the First Clinical Medicine College, 2.Clinical Laboratory, the First Hospital, 3.Department of Nuclear Medicine, the First Hospital, 4.Pharmacological College, Lanzhou University, Lanzhou 730000, China
  • Online:2014-12-28 Published:2014-12-30
  • Supported by:

    National Science and Technology Major Project of the Ministry of Science and Technology of China during the “10th Five-Year Plan”,2002DA711A028-17; Science and Technology Foundation Construction of Ministry of Education, 505015; Natural Science Foundation of Gansu Province,1308RJZA218

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摘要：

目的 探讨高三酰甘油血症对心脑血管终点事件的影响及意义。方法 利用家族性高三酰甘油血症2个家系10年资料，观察家系成员心脑血管终点事件的发生情况。结果 家系1中Ⅲ1在研究当年因出血性脑卒中去世；Ⅲ3在研究第3年因出血性脑卒中去世；其余成员均无心脑血管终点事件发生。家系2所有成员10年随访无心脑血管终点事件发生。结论 家族性高三酰甘油血症家系中单纯三酰甘油升高不会发生心脑血管终点事件；当有高血压危险因素存在时，高三酰甘油血症患者的脑血管终点事件增加。

关键词: 家族性高三酰甘油血症, 家系, 心脑血管终点事件, 随访

Abstract:

Objective To investigate the effects of hypertriglyceridemia on cardiac and cerebral vascular endpoint events. Methods The data of familial hypertriglyceridemia in 10 years were collected and the occurrence of cardiac and cerebral vascular endpoint events of 2 family members was observed. Results In Family 1, Ⅲ 1 died of hemorrhagic stroke in the first year of study and Ⅲ 3 died of hemorrhagic stroke in the third year of study. Cardiac and cerebral vascular endpoint events did not occur among the rest family members. In Family 2, no cardiac and cerebral vascular endpoint events occurred. Conclusion For familial hypertriglyceridemia, pure hypertriglyceridemia does not cause cardiac and cerebral vascular endpoint events. The occurrence of cerebrovascular endpoint events increases with the presence of hypertension.

Key words: familial hypertriglyceridemia, family, cardiac and cerebral vascular events, follow-up