上海交通大学学报（医学版）

上海交通大学学报（医学版）

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GPRC6A及其糖稳态调节作用研究进展

杜 婧，包玉倩   

  1. 上海交通大学附属第六人民医院内分泌代谢科 上海市糖尿病临床医学中心 上海市糖尿病研究所 上海市糖尿病重点实验室, 上海 200233
  • 出版日期:2015-01-28 发布日期:2015-01-29
  • 作者简介:杜 婧(1982—)， 女， 主治医师， 博士生; 电子信箱: du_lilian@aliyun.com。
  • 基金资助:

    国家自然科学基金(81170788)

Advances of GPRC6A and its regulation function of glucose homeostasis

DU Jing, BAO Yu-qian   

  1. Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China
  • Online:2015-01-28 Published:2015-01-29
  • Supported by:

    National Natural Science Foundation of China, 81170788

PDF (PC)

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摘要：

G蛋白耦联受体C家族6组A（GPRC6A）是近年来新发现的一种G蛋白耦联受体，可与多种配体如钙离子、碱性氨基酸、骨钙素、睾酮等结合发挥生理作用，并参与机体的糖稳态调节。GPRC6A缺失可能引起糖代谢失衡。深入研究GPRC6A及其糖稳态调节作用可能为糖尿病提供一个新的药物治疗靶点。

关键词: GPRC6A, 糖稳态, G蛋白耦联受体, 骨钙素

Abstract:

The G protein coupled receptor family C, group 6, subtype A (GPRC6A) is a newly identified G protein coupled receptor, which involves in a broad range of physiological functions by combining with various ligands, such as calcium, basic amino acid, osteocalcin, and steroid, as well as the regulation of glucose homeostasis. Deletion of GPRC6A may cause disturbance of glucose homeostasis. Further study on GPRC6A and its regulation function of glucose homeostasis may identify a new therapeutic target for diabetes.

Key words: GPRC6A, glucose homeostasis, G protein coupled receptor, osteocalcin