上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 综述 • 上一篇    下一篇

黄体生成素受体mRNA结合蛋白的研究进展

范梦夏，乔洁   

  1. 上海交通大学   医学院附属第九人民医院内分泌代谢科， 上海 200011
  • 出版日期:2015-06-28 发布日期:2015-07-30
  • 通讯作者: 乔洁, 电子信箱: qiaoj2001@126.com。
  • 作者简介:范梦夏（1988—）， 女， 硕士生; 电子信箱: fanmengxia2012@yeah.net。

Research progresses of luteinizing hormone receptor mRNA binding protein

FAN Meng-xia, QIAO Jie   

  1. Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital， Shanghai Jiao Tong University School of Medicine, Shanghai  200011, China
  • Online:2015-06-28 Published:2015-07-30

PDF (PC)

1067

摘要：

黄体生成素受体（LHR）在生殖和发育过程中发挥重要作用。女性排卵前期的黄体生成素（LH）峰及药理剂量的人绒毛膜促性腺激素（hCG）可导致LHR的下调，而在受体下调的大鼠卵巢细胞质中发现LHR mRNA结合蛋白（LRBP）。研究表明，LH/hCG与受体结合后激活cAMP/PKA/ERK通路及miR-122表达，导致LRBP表达量增加；LHR mRNA与LRBP结合后，诱导翻译沉默，并转移至P小体，导致LHR mRNA降解，与排卵前期受体的脱敏过程密切相关。该文就LRBP的研究进展进行综述。

关键词: 黄体生成素受体, 黄体生成素受体mRNA结合蛋白, P小体

Abstract:

Luteinizing hormone receptor (LHR) plays a crucial role in the processes of reproduction and development. LHR can be down-regulated in response to preovulatory luteinizing hormone (LH) surge or by the administration of a pharmacological dose of human chorionic gonadotropin (hCG). LHR mRNA binding protein (LRBP) has been identified in ovarian cytoplasm of rats with down-regulated receptor. Researches show that the binding of LH/hCG and their receptors can stimulate the cAMP/PKA/ERK signaling pathway and expression of miR-122, which result in the increase of LRBP expression. The binding of LRBP with LHR mRNA can induce the suppression of translation and transfer to the p-bodies, which is closely relevant to the desensitivity of LHR during preovulatory phase. This paper reviews the research progresses of LRBP.

Key words: luteinizing hormone receptor, luteinizing hormone receptor mRNA binding protein, P-bodies