上海交通大学学报（医学版）

上海交通大学学报（医学版）

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抑郁症海马的结构及功能磁共振成像的研究进展

邱美慧，吴彦，彭代辉   

  1. 上海交通大学 医学院附属精神卫生中心心境障碍科，上海 200030
  • 出版日期:2015-06-28 发布日期:2015-07-30
  • 通讯作者: 彭代辉, 电子信箱: pdhsh@126.com。
  • 作者简介:邱美慧（1988—）， 女， 硕士生; 电子信箱: qmh514@sina.com。
  • 基金资助:

    上海交通大学科研基金（11XJ21006, YG2012MS11）；上海市科委基金（134119a6200）；上海市卫生局海外人才项目（GWHW201208）

Research progresses of structure and functional magnetic resonance imaging of hippocampus

QIU Mei-hui, WU Yan, PENG Dai-hui   

  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2015-06-28 Published:2015-07-30
  • Supported by:

    Research Fund of Shanghai Jiao Tong University，11XJ21006, YG2012MS11；Foundation of Science and Technology Commission of Shanghai Municipality，134119a6200；Overseas Talent Project Fund of Shanghai Health Bureau，GWHW201208

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摘要：

近几年有关抑郁症神经影像学的研究发展较快，有证据表明抑郁症患者存在脑结构和功能的改变。海马是边缘系统中一个重要的脑区，与抑郁症患者的异常情绪调节及认知功能缺损相关。该文对抑郁症患者海马的结构与功能磁共振成像的研究进展进行综述，以探讨抑郁症海马的生物学机制。

关键词: 抑郁症, 海马, 磁共振成像

Abstract:

With the rapid development of neuroimaging in recent years, increasing evidences indicate that there are alterations of brain structure and function in patients with major depressive disorder. As an important region in limbic system, hippocampus is relevant to abnormal emotional regulation and cognitive impairment. This paper reviews the research advances of structure and functional magnetic resonance imaging of hippocampus of patients with major depressive disorder and discusses the biological mechanisms of hippocampus of patients with major depressive disorder.

Key words: major depressive disorder, hippocampus, magnetic resonance imaging