上海交通大学学报（医学版）

上海交通大学学报（医学版）

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硫化氢治疗阿尔茨海默病的机制研究进展

赵丰丽，晏勇   

  1. 重庆医科大学附属第一医院神经内科， 重庆 400016
  • 出版日期:2015-06-28 发布日期:2015-07-30
  • 作者简介:赵丰丽(1985—), 女, 博士生; 电子信箱: zhaoflhh@163.com。
  • 基金资助:

    国家自然科学基金(81271222)

Research advances of mechanism of treating Alzheimer's disease by hydrogen sulfide

ZHAO Feng-li, YAN Yong   

  1. Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • Online:2015-06-28 Published:2015-07-30
  • Supported by:

    National Natural Science Foundation of China，81271222

PDF (PC)

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摘要：

内源性气体介质——硫化氢(H2S)，可调节哺乳动物一系列生理病理过程。近年来，中枢神经系统(CNS)内H2S的生理病理作用引起大家广泛关注。H2S作为神经调质，可促进海马长时程增强和调节脑细胞内Ca2+浓度和pH值。H2S可保护神经系统免受氧化应激、细胞凋亡或变性损伤。阿尔茨海默病(AD)病理过程中存在H2S失调。文章就H2S保护AD的潜在机制研究作一综述。

关键词: 硫化氢, 阿尔茨海默病, 炎症, 氧化应激, 凋亡

Abstract:

Hydrogen sulfide (H2S) is an endogenously generated gaseous mediator and can regulate a series of physiological and pathological processes of mammals. In recent years, the physiological and pathological effects of H2S on the central nervous system attract more and more attention. H2S can promote the longterm potentiation of hippocampus and regulate the intracellular calcium concentration and pH level of brain cells as a neuromodulator. H2S can also protect the nervous system from oxidative stress, apoptosis, or degeneration. Dysregulation of H2S is implicated in the pathological processes of Alzheimer's disease (AD). This paper reviews the potential mechanism of protective role of H2S in AD.

Key words: hydrogen sulfide, Alzheimer's disease, inflammatory, oxidative stress, apoptosis