重性抑郁障碍相关睡眠表现及其潜在机制的研究进展

doi:10.3969/j.issn.1674-8115.2026.06.012

摘要/Abstract

摘要：

重性抑郁障碍（major depressive disorder，MDD）是一种常见的精神障碍，在全球范围内呈现高患病率、高致残率特征，给社会及家庭造成沉重的疾病负担。睡眠问题在MDD患者中十分普遍，其不仅是MDD的症状之一，也与MDD发生、迁延与复发密切相关，严重影响患者的社会功能与生活质量。该文系统梳理了MDD患者常见的睡眠问题与相关神经生物学机制，同时归纳了临床干预手段及作用机制，以期为MDD及其合并睡眠问题的临床干预提供科学理论支撑。

关键词: 重性抑郁障碍, 睡眠特征, 神经生物学机制, 炎症因子

Abstract:

Major depressive disorder (MDD) is a common psychiatric disorder. It features high prevalence and high disability rates globally, imposing a heavy disease burden on society and families. Sleep problems are highly prevalent among patients with MDD, which are not only one of the core symptoms of MDD, but are also closely related to its onset, persistence, and recurrence, severely impairing patients' social functioning and quality of life. This article systematically reviews the common sleep problems in patients with MDD and the associated neurobiological mechanisms, and summarizes current clinical intervention strategies and their underlying mechanisms, aiming to provide scientific theoretical support for the clinical intervention of MDD and its comorbid sleep problems.

Key words: major depressive disorder (MDD), sleep characteristics, neurobiological mechanism, inflammatory factor

中图分类号:

R749.4

朱墨, 陈俊. 重性抑郁障碍相关睡眠表现及其潜在机制的研究进展[J]. 上海交通大学学报（医学版）, 2026, 46(6): 795-800.

Zhu Mo, Chen Jun. Research progress in sleep manifestations related to major depressive disorder and its potential mechanisms[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(6): 795-800.

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