β-抑制蛋白1在炎症反应调控中作用的研究进展

doi:10.3969/j.issn.1674-8115.2024.12.013

上海交通大学学报（医学版） ›› 2024, Vol. 44 ›› Issue (12): 1593-1600.doi: 10.3969/j.issn.1674-8115.2024.12.013

• 综述 • 上一篇

β-抑制蛋白1在炎症反应调控中作用的研究进展

衣文婧(), 范宜璇, 仇佳泰, 付晓燕, 刘梅芳()

山东第二医科大学基础医学院免疫微环境与炎症性疾病研究特色实验室，潍坊 261053

收稿日期:2024-02-01 接受日期:2024-09-03 出版日期:2024-12-16 发布日期:2024-12-16
通讯作者: 刘梅芳 E-mail:2682445008@qq.com;lmf00719@163.com
作者简介:衣文婧（2002—），女，本科生；电子信箱：2682445008@qq.com。
基金资助:
国家自然科学基金(82000525);山东省大学生创新创业训练计划(S202310438068);山东省高等学校青创科技支持计划(2021KJ106);山东省自然科学基金(ZR2023MH359);山东省高等学校青创人才引育计划“免疫微环境与炎症性疾病研究创新团队”

Research progress in the role of β-arrestin 1 in the regulation of inflammatory response

YI Wenjing(), FAN Yixuan, QIU Jiatai, FU Xiaoyan, LIU Meifang()

Key Laboratory of Immune Microenvironment and Inflammatory Disease Research, School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, China

Received:2024-02-01 Accepted:2024-09-03 Online:2024-12-16 Published:2024-12-16
Contact: LIU Meifang E-mail:2682445008@qq.com;lmf00719@163.com
Supported by:
National Natural Science Foundation of China(82000525);Shandong Provincial College Student Innovation and Entrepreneurship Training Program(S202310438068);Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province(2021KJ106);Natural Science Foundation of Shandong Province(ZR2023MH359);Shandong Provincial Higher Education Youth Talent Introduction Program "Immune Microenvironment and Inflammatory Disease Research Innovation Team"

摘要/Abstract

摘要：

炎症反应是机体应对感染或损伤等刺激时产生的系统性响应过程，与多种疾病的发生机制密切相关，并在疾病进展与转归过程中起着重要作用。正常情况下，炎症反应能够在机体受损不严重时做出响应并维持组织稳态；而在受到较严重的刺激时，失控的炎症反应往往会对机体造成严重危害。理想的炎症反应是在消除了炎症刺激后终止响应，因此有效调控炎症反应的程度和范围显得尤为重要。β-抑制蛋白1（β-arrestin 1，ARRB1）是一种多功能调节蛋白，在G蛋白偶联受体（G protein-coupled receptor，GPCR）和非GPCR介导的信号转导中发挥关键作用；同时，该蛋白还参与部分免疫细胞发育、分化等功能的调控。尽管ARRB1最初被认为是GPCR信号转导的终止子，可抑制炎症反应，但近年来的研究提示ARRB1在炎症反应中的作用较为复杂，具有抑制炎症和促进炎症的双重作用。基于此，该文回顾了近年来ARRB1与炎症反应的相关研究，详细阐述并讨论了ARRB1对信号通路转导和免疫细胞发育、分化功能的调控作用以及其调控炎症性疾病进展的作用机制，以期为炎症性疾病的临床精准治疗和药物效应靶点的筛选提供新思路。

关键词: β-抑制蛋白1, 抑制炎症作用, 促进炎症作用, 信号通路, 免疫细胞, 炎症因子

Abstract:

The inflammatory response is a systemic process produced by the body in response to stimulation such as infection or injury. The inflammatory response is closely related to the pathogenesis of various diseases, and plays an important role in the progression and outcome of diseases. Under normal conditions, the inflammatory response can maintain tissue homeostasis when the body is not seriously damaged. However, an uncontrolled inflammatory response that occurs when the body is subjected to more severe stimuli may often cause serious harm to the body. The termination of the ideal inflammatory response occurs after the elimination of the inflammatory stimulus. Therefore, it is particularly important to effectively modulate the extent and scope of the inflammatory response. β-arrestin 1 (ARRB1) is a multifunctional regulatory protein that plays a key role in G protein-coupled receptor (GPCR) and non-GPCR-mediated signal transduction. Meanwhile, this protein also participates in the regulation of some immune cell development, differentiation and other functions. Although ARRB1 was originally thought to be a terminator of GPCR signal transduction and can inhibit the inflammatory response, recent studies suggest that its role in inflammatory responses is complex, with dual anti-inflammatory and pro-inflammatory effects. Based on this, this article reviews the relevant research on ARRB1 and the inflammatory response in recent years, focusing on the regulatory role of ARRB1 in signaling pathway transduction and immune cell development and differentiation function, as well as its mechanism of action in regulating the progression of inflammatory diseases, in order to provide new insights for the clinical precision treatment of inflammatory diseases and the screening of drug effect targets.

Key words: β-arrestin 1 (ARRB1), anti-inflammatory role, pro-inflammatory role, signaling pathway, immune cell, inflammatory factor

中图分类号:

R392

衣文婧, 范宜璇, 仇佳泰, 付晓燕, 刘梅芳. β-抑制蛋白1在炎症反应调控中作用的研究进展[J]. 上海交通大学学报（医学版）, 2024, 44(12): 1593-1600.

YI Wenjing, FAN Yixuan, QIU Jiatai, FU Xiaoyan, LIU Meifang. Research progress in the role of β-arrestin 1 in the regulation of inflammatory response[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(12): 1593-1600.

图/表 4

图1 ARRB1调控细胞内信号转导的相关机制示意图Note： A. ARRB1 is involved in GPCR desensitization and activation of G-protein-independent signaling pathways. B. ARRB1 is involved in receptor internalization.

Fig 1 Schematic diagram of the mechanism by which ARRBl regulates intracellular signal transduction

图2 ARRB1在T细胞发育中的调控作用示意图

Fig 2 Schematic diagram of the regulatory role of ARRB1 in T cell development

图3 ARRB1促进炎症反应的机制总结图示Note： IκBα—inhibitor-κ binding protein α; HCC—hepatocellular carcinoma; PD—Parkinson's disease; RA—rheumatoid arthritis.

Fig 3 Summary diagram of the mechanism of ARRB1 promoting inflammatory response

图 4 ARRB1抑制炎症反应的机制总结图示Note： AP—acute pancreatitis.

Fig 4 Summary diagram of the mechanism by which ARRB1 inhibits inflammatory response

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β-抑制蛋白1在炎症反应调控中作用的研究进展

Research progress in the role of β-arrestin 1 in the regulation of inflammatory response

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