精氨酸代谢调控间充质干细胞功能的研究进展

doi:10.3969/j.issn.1674-8115.2025.07.013

摘要/Abstract

摘要：

间充质干细胞（mesenchymal stem cells，MSCs）是一类存在于骨髓、脂肪、脐带血、骨骼、肌肉等多种组织中的成体干细胞，不仅具有干细胞特有的自我更新能力和多向分化潜能，还具有免疫调节功能。精氨酸是一种条件必需氨基酸，其代谢调控对维持细胞功能和机体健康至关重要。精氨酸代谢可能对MSCs的增殖和分化、炎症反应的发生，以及肿瘤发展均有一定影响。该文总结精氨酸代谢对不同种类MSCs分化的作用及其与炎症、免疫、肿瘤发展之间的关系，探讨代谢综合征治疗的新策略，从精氨酸代谢角度为MSCs治疗炎症性疾病、肿瘤等提供新思路。

关键词: 间充质干细胞, 精氨酸代谢, 分化, 炎症

Abstract:

Mesenchymal stem cells (MSCs) are adult stem cells that exist in bone marrow, fat, cord blood, bone, muscle and other tissues. MSCs not only have the unique self-renewal ability and multidirectional differentiation potential of stem cells, but also have the function of immune regulation. Arginine is a conditionally essential amino acid, and its metabolic regulation is essential for maintaining cell function and overall health. In MSCs, arginine metabolism may have a certain effect on cell proliferation, differentiation, inflammatory response, and tumor development. This article summarizes the effects of arginine metabolism on the differentiation, inflammation, immunity, and tumor development in different types of MSCs, discusses new strategies for the treatment of metabolic syndrome, and provides new ideas for the treatment of inflammatory diseases and tumors by MSCs from the perspective of arginine metabolism.

Key words: mesenchymal stem cells, arginine metabolism, cell differentiation, inflammation

中图分类号:

赛提尔古丽·克然木, 钱蕾, 丁思怡, 哈娜提·马合力木汗, 杨雪儿, 贾浩. 精氨酸代谢调控间充质干细胞功能的研究进展[J]. 上海交通大学学报（医学版）, 2025, 45(7): 910-915.

KERANMU Saitierguli, QIAN Lei, DING Siyi, MAHELIMUHAN Hanati, YANG Xueer, JIA Hao. Research progress of arginine metabolism in the regulation of mesenchymal stem cell function[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(7): 910-915.

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