上海交通大学学报(医学版) ›› 2024, Vol. 44 ›› Issue (6): 779-787.doi: 10.3969/j.issn.1674-8115.2024.06.014
曾德洁1,2(), 陈增辉1, 丁乾坤1, 孙夏青1, 孙琪1, 赵士兵1,2(
)
收稿日期:
2024-01-04
接受日期:
2024-03-19
出版日期:
2024-06-28
发布日期:
2024-06-28
通讯作者:
赵士兵
E-mail:zengdejie@stu.bbmc.edu.cn;zhaoshibing523@163.com
作者简介:
曾德洁(1995—),女,硕士生;电子信箱:zengdejie@stu.bbmc.edu.cn。
基金资助:
ZENG Dejie1,2(), CHEN Zenghui1, DING Qiankun1, SUN Xiaqing1, SUN Qi1, ZHAO Shibing1,2(
)
Received:
2024-01-04
Accepted:
2024-03-19
Online:
2024-06-28
Published:
2024-06-28
Contact:
ZHAO Shibing
E-mail:zengdejie@stu.bbmc.edu.cn;zhaoshibing523@163.com
Supported by:
摘要:
神经发育障碍(neurodevelopmental disorders,NDDs)是由于多种遗传性或者获得性病因导致的可影响认知、运动、社会适应能力、行为等的慢性发育性脑功能障碍性疾病。天然多糖是生物体合成的,位于细胞壁、细胞内、细胞间以及分泌至细胞外的生物大分子,是生命活动的必需成分。天然多糖在神经性疾病中发挥重要作用,主要通过抗氧化应激、抗神经细胞凋亡、抗神经炎症、抗兴奋性氨基酸毒性和调节脑-肠轴等途径,改善神经性疾病引起的行为异常和临床症状。该文综述17种来自植物和真菌的生物活性多糖在神经性疾病中的干预作用,旨在为NDDs疾病的研究及治疗提供新的思路。
中图分类号:
曾德洁, 陈增辉, 丁乾坤, 孙夏青, 孙琪, 赵士兵. 天然来源的多糖在干预神经发育障碍中的应用前景[J]. 上海交通大学学报(医学版), 2024, 44(6): 779-787.
ZENG Dejie, CHEN Zenghui, DING Qiankun, SUN Xiaqing, SUN Qi, ZHAO Shibing. Prospect of naturally derived polysaccharides in intervention in neurodevelopmental disorders[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(6): 779-787.
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