天然来源的多糖在干预神经发育障碍中的应用前景

doi:10.3969/j.issn.1674-8115.2024.06.014

上海交通大学学报（医学版） ›› 2024, Vol. 44 ›› Issue (6): 779-787.doi: 10.3969/j.issn.1674-8115.2024.06.014

天然来源的多糖在干预神经发育障碍中的应用前景

曾德洁¹^,²(), 陈增辉¹, 丁乾坤¹, 孙夏青¹, 孙琪¹, 赵士兵¹^,²()

^1.蚌埠医科大学研究生院，蚌埠 233030
^2.蚌埠医科大学第一附属医院重症医学科，蚌埠 233004

收稿日期:2024-01-04 接受日期:2024-03-19 出版日期:2024-06-28 发布日期:2024-06-28
通讯作者: 赵士兵 E-mail:zengdejie@stu.bbmc.edu.cn;zhaoshibing523@163.com
作者简介:曾德洁（1995—），女，硕士生；电子信箱：zengdejie@stu.bbmc.edu.cn。
基金资助:
国家自然科学基金(32000822);蚌埠医科大学研究生科研创新计划(Byycx23027)

Prospect of naturally derived polysaccharides in intervention in neurodevelopmental disorders

ZENG Dejie¹^,²(), CHEN Zenghui¹, DING Qiankun¹, SUN Xiaqing¹, SUN Qi¹, ZHAO Shibing¹^,²()

^1.Postgraduate Research Institute, Bengbu Medical University, Bengbu 233030, China
^2.Department of Critical Care Medicine, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China

Received:2024-01-04 Accepted:2024-03-19 Online:2024-06-28 Published:2024-06-28
Contact: ZHAO Shibing E-mail:zengdejie@stu.bbmc.edu.cn;zhaoshibing523@163.com
Supported by:
National Natural Science Foundation of China(32000822);Graduate Research Innovation Program of Bengbu Medical University(Byycx23027)

摘要/Abstract

摘要：

神经发育障碍（neurodevelopmental disorders，NDDs）是由于多种遗传性或者获得性病因导致的可影响认知、运动、社会适应能力、行为等的慢性发育性脑功能障碍性疾病。天然多糖是生物体合成的，位于细胞壁、细胞内、细胞间以及分泌至细胞外的生物大分子，是生命活动的必需成分。天然多糖在神经性疾病中发挥重要作用，主要通过抗氧化应激、抗神经细胞凋亡、抗神经炎症、抗兴奋性氨基酸毒性和调节脑-肠轴等途径，改善神经性疾病引起的行为异常和临床症状。该文综述17种来自植物和真菌的生物活性多糖在神经性疾病中的干预作用，旨在为NDDs疾病的研究及治疗提供新的思路。

关键词: 神经发育障碍, 天然多糖, 氧化应激, 神经炎症, 神经保护

Abstract:

Neurodevelopmental disorders (NDDs) are chronic developmental brain disorders that can affect cognition, motor, social adaptation, behavior and so on due to multiple genetic or acquired causes. Natural polysaccharides are synthesized by living organisms, located in the cell wall, inside and between cells, and outside the cells, and are essential components of life activities. Previous studies have found that natural polysaccharides play an important role in neurological diseases, which mainly ameliorate the behavioral abnormalities and clinical symptoms caused by anti-oxidative stress, anti-neuronal apoptosis, anti-neuroinflammation, anti-excitatory amino acid toxicity, and regulation of the brain-gut axis. This review summarizes the intervention role of 17 bioactive polysaccharides from plants and fungi in neurological diseases, aiming to provide new ideas for the research and treatment of NDDs.

Key words: neurodevelopmental disorders, natural polysaccharides, oxidative stress, neuroinflammation, neuroprotection

中图分类号:

R741.02

曾德洁, 陈增辉, 丁乾坤, 孙夏青, 孙琪, 赵士兵. 天然来源的多糖在干预神经发育障碍中的应用前景[J]. 上海交通大学学报（医学版）, 2024, 44(6): 779-787.

ZENG Dejie, CHEN Zenghui, DING Qiankun, SUN Xiaqing, SUN Qi, ZHAO Shibing. Prospect of naturally derived polysaccharides in intervention in neurodevelopmental disorders[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(6): 779-787.

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天然来源的多糖在干预神经发育障碍中的应用前景

Prospect of naturally derived polysaccharides in intervention in neurodevelopmental disorders

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