饮食炎症指数与抑郁障碍关系的研究进展

doi:10.3969/j.issn.1674-8115.2026.10.010

上海交通大学学报（医学版） ›› 2026, Vol. 46 ›› Issue (10): 1406-1411.doi: 10.3969/j.issn.1674-8115.2026.10.010

• 综述 • 上一篇

饮食炎症指数与抑郁障碍关系的研究进展

李彬阁¹, 王凡¹, 徐欣然¹, 许鑫¹, 陈依明¹, 洪武¹^,²^,³()

^1.上海交通大学医学院附属精神卫生中心，上海 200030
^2.上海市重性精神病重点实验室，上海 200030
^3.上海交通大学中国医院发展研究院心理健康管理研究所，上海 200030

收稿日期:2026-01-23 接受日期:2026-04-09 出版日期:2026-10-19 发布日期:2026-10-19
通讯作者: 洪武，主任医师，博士；电子信箱：drhongwu@126.com。
基金资助:
科技创新2030—“脑科学与类脑研究”重大项目(2021ZD0200800);上海市“科技创新行动计划”医学创新研究专项(21Y11905600);上海市“科技创新行动计划”自然科学基金(21ZR1455100);上海市精神卫生中心院级课题(2024-YJ03)

Research progress in the association between dietary inflammatory index and major depressive disorder

Li Binge¹, Wang Fan¹, Xu Xinran¹, Xu Xin¹, Chen Yiming¹, Hong Wu¹^,²^,³()

^1.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
^2.Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, China
^3.Mental Health Branch, China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai 200030, China

Received:2026-01-23 Accepted:2026-04-09 Online:2026-10-19 Published:2026-10-19
Contact: Hong Wu, E-mail: drhongwu@126.com.
Supported by:
National Science and Technology Innovation 2030—Major Project of Brain Science and Brain-inspired Research(2021ZD0200800);Special Project for Medical Innovation Research under “Shanghai Action Plan for Science, Technology and Innovation”(21Y11905600);Natural Science Foundation of Shanghai under“Shanghai Action Plan for Science, Technology and Innovation”(21ZR1455100);Program of Shanghai Mental Health Center(2024-YJ03)

摘要/Abstract

摘要：

饮食炎症指数（dietary inflammatory index，DII）是一种用于评估饮食炎症潜力的重要工具。随着抑郁炎症假说的不断发展，DII已广泛应用于抑郁障碍（major depressive disorder，MDD）的相关研究中，且越来越多的研究发现较高DII与MDD发生风险存在显著关联。在此背景下，该文概述DII的构建依据及计算方法，介绍基于DII衍生的评估工具的优势和局限性。通过总结近年研究分析发现高DII人群的促炎饮食模式是MDD发生的一项危险因素，提示DII与MDD相关结局发生风险间存在量效关系。促炎饮食可通过增加内脏脂肪堆积、破坏肠道免疫稳态与屏障完整性，诱导机体产生慢性低度炎症，增强外周炎症信号向中枢神经系统的传递，进而激活小胶质细胞，抑制脑源性神经营养因子（brain-derived neurotrophic factor，BDNF）的分泌，干扰色氨酸代谢，最终导致MDD的发生发展。该文为理解饮食与MDD的关系提供了新视角，也为MDD的治疗与综合预防指明了新方向。未来仍需高质量的临床研究来明确抗炎饮食对MDD治疗及预防的临床价值，推进DII在精神医学领域的临床应用。

关键词: 饮食炎症指数, 促炎饮食, 抑郁障碍, 神经炎症, 脑-肠轴, 色氨酸代谢

Abstract:

The dietary inflammatory index (DII) is an important tool for assessing the inflammatory potential of diet. With the continued development of the inflammatory hypothesis of depression, DII has been widely applied in studies of major depressive disorder (MDD), and an increasing number of studies have found a significant association between higher DII scores and an increased risk of MDD. Against this background, this article outlines the rationale for the construction of DII and its calculation methods and introduces the advantages and limitations of assessment tools derived from DII. A review of recent studies reveals that a pro-inflammatory dietary pattern among individuals with high DII scores is a risk factor for the development of MDD, suggesting a dose-response relationship between DII and the risk of depression-related outcomes. Pro-inflammatory diets can induce chronic low-grade inflammation by increasing visceral fat accumulation and disrupting intestinal immune homeostasis and barrier integrity. This inflammation can enhance the transmission of peripheral inflammatory signals to the central nervous system, thereby activating microglia, inhibiting the secretion of brain-derived neurotrophic factor (BDNF), and interfering with tryptophan metabolism, ultimately leading to the occurrence and development of MDD. This article provides a new perspective on understanding the relationship between diet and MDD and also points to new directions for the treatment and comprehensive prevention of MDD. In the future, high-quality clinical research is still needed to clarify the clinical value of anti-inflammatory diets in the treatment and prevention of MDD, and to promote the clinical application of DII in psychiatry.

Key words: dietary inflammatory index (DII), pro-inflammatory diet, major depressive disorder (MDD), neuroinflammation, brain-gut axis, tryptophan metabolism

中图分类号:

R749.4

李彬阁, 王凡, 徐欣然, 许鑫, 陈依明, 洪武. 饮食炎症指数与抑郁障碍关系的研究进展[J]. 上海交通大学学报（医学版）, 2026, 46(10): 1406-1411.

Li Binge, Wang Fan, Xu Xinran, Xu Xin, Chen Yiming, Hong Wu. Research progress in the association between dietary inflammatory index and major depressive disorder[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026,(10): 1406-1411.

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饮食炎症指数与抑郁障碍关系的研究进展

Research progress in the association between dietary inflammatory index and major depressive disorder

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