上海交通大学学报（医学版）

上海交通大学学报（医学版）

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胱抑素C作为对比剂肾损伤的早期诊断生物标志物的研究进展

张维峰，沈玲红，何奔   

  1. 上海交通大学 医学院附属仁济医院心内科， 上海 200127
  • 出版日期:2015-08-28 发布日期:2015-09-30
  • 通讯作者: 何奔, 电子信箱: heben@medmail.com.cn。
  • 作者简介:张维峰（1989—）， 男， 博士生; 电子信箱: charliezhang@126.com。

Research progresses of biomarkers for early diagnosis of contrast-induced acute kidney injury by cystatin C

ZHANG Wei-feng, SHEN Ling-hong, HE Ben   

  1. Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2015-08-28 Published:2015-09-30

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摘要：

随着介入治疗、CT和三维重建新技术的发展及血管内造影剂的使用，对比剂肾损伤（CI-AKI）的发生率显著上升。早期诊断CI-AKI可及时治疗并显著改善患者的预后。然而，血清肌酐（SCr）作为急性肾损伤（AKI）的诊断标志物却有着延后性与不可靠性。随着研究的进展，胱抑素C（CysC）生物标志物引起了人们广泛关注，为CI-AKI的早期诊断，甚至为预测主要心血管不良事件（MACE）的发生提供了可能。该文对近年来相关CysC作为早期诊断CI-AKI的标志物及预测MACE的研究作一综述，探讨CysC的应用可能及前景。

关键词: 对比剂肾损伤, 胱抑素C, 早期诊断, 主要心血管不良事件

Abstract:

With the development of intervention therapy, CT, and three dimension reconstruction technology and the application of intravascular contrast media, the incidence of contrast-induced acute kidney injury (CI-AKI) increased rapidly. Early diagnosis of CI-AKI contributes to timely treatment and significantly improves the prognosis. However, it is lagging and unreliable to use serum creatine (SCr) as a biomarker for the diagnosis of acute kidney injury (AKI). With the development of research, much attention has been paid to the biomarker of cystatin C (CysC), which seems to provide the possibility for the early diagnosis of CI-AKI and predicting the incidence of major adverse cardiac events (MACE). This paper reviews recent researches relevant to using CysC as the biomarker for early diagnosis of CI-AKI and prediction of MACE and discusses the possibility and prospect of application of CysC.

Key words: contrast-induced acute kidney injury, cystatin C, early diagnosis, major adverse cardiac events