上海交通大学学报（医学版）

上海交通大学学报（医学版）

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HGF/c-Met与胃癌靶向治疗的研究进展

朱雪茹，郑磊贞   

  1. 上海交通大学 医学院附属新华医院肿瘤科， 上海 200092
  • 出版日期:2016-01-28 发布日期:2016-02-26
  • 通讯作者: 郑磊贞, 电子信箱: zhengleizhen2006@126.com。
  • 作者简介:朱雪茹（1991—）， 女， 硕士生; 电子信箱: 15061962112@163.com。

Research progress of HGF/c-Met-related targeted therapy of gastric cancer

ZHU Xue-ru, ZHENG Lei-zhen   

  1. Department of Oncology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2016-01-28 Published:2016-02-26

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摘要：

胃癌是最常见的恶性肿瘤之一，大部分患者在诊断时已属晚期。近年来，尽管胃癌诊治技术得到了较好的发展，但肿瘤的局部浸润和转移等问题仍阻碍了胃癌的预后，晚期胃癌的5年存活率仍然很低。随着分子生物学的发展，许多新的靶向治疗药物成为研究热点，部分药物已进入临床研究中。肝细胞生长因子及其受体（HGF/c-Met）信号通路与胃癌的发生、发展、转移及预后有密切的关系，是胃癌靶向治疗极具潜力的靶点。该文就该信号通路的结构和功能、对胃癌发生发展的影响以及靶向该信号通路的胃癌治疗药物的研究进展进行综述。

关键词: 胃癌, 靶向治疗, HGF/c-Met

Abstract:

Gastric cancer is one of the most common malignancies and most patients have been at the advanced stage when they were diagnosed. In recent years, although diagnosis and treatment techniques of gastric cancer develop rapidly, problems such as local infiltration and metastasis still affect the prognosis of gastric cancer. The 5-year survival rate of patients with advanced gastric cancer remains very low. With the development of molecular biology, many novel targeted agents have been research hotspots and some of them are at the phase of clinical research. Hepatocyte growth factor/cellular-mesenchymal to epithelial transition factor (HGF/c-Met) signaling pathway is closely correlated with the occurrence, development, metastasis, and prognosis of gastric cancer and is a potential target for the targeted therapy of gastric cancer. This paper reviews research progresses of structures and functions of HGF/c-Met signaling pathway, effects of HGF/c-Met signaling pathway on the occurrence and development of gastric cancer, and HGF/c-Met signaling pathway-related targeted agents of gastric cancer.

Key words: gastric cancer, targeted , therapy, HGF/c-Met