上海交通大学学报（医学版）

上海交通大学学报（医学版）

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Rho/Rock信号通路与肺纤维化相关性的研究进展

漆秀洁1,2， 李静3， 谭利平1， 许峰3， 方芳2   

  1. 1.重庆医科大学附属儿童医院急诊科， 重庆 400014； 2.重庆医科大学附属儿童医院, 重庆市住院医师规范化培训基地, 儿童发育疾病研究教育部重点实验室, 儿童发育重大疾病国家国际科技合作基地, 儿科学重庆市重点实验室， 重庆 400014； 3.重庆医科大学附属儿童医院PICU， 重庆 400014
  • 出版日期:2016-10-28 发布日期:2016-11-29
  • 通讯作者: 李静， 电子信箱： lijingwangyi@126.com。
  • 作者简介:漆秀洁（1987—）， 女， 硕士生； 电子信箱： 250931419@qq.com。
  • 基金资助:

    国家自然科学基金（81101442）

Research progresses of the correlation between Rho/Rock signaling pathway and pulmonary fibrosis

QI Xiu-jie1,2, LI Jing3, TAN Li-ping1, XU Feng3, FANG Fang2   

  1. 1.Department of Emergency, Childrens Hospital of Chongqing Medical University, Chongqing 400014, China; 2.Chongqing Key Laboratory of Pediatrics, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Training Base of Clinical Resident Standard Training in Chongqing, Childrens Hospital of Chongqing Medical University, Chongqing 400014, China; 3.Department of Pediatric Intensive Care Unit, Childrens Hospital of Chongqing Medical University, Chongqing 400014, China
  • Online:2016-10-28 Published:2016-11-29
  • Supported by:

    National Natural Science Foundation of China, 81101442

PDF (PC)

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摘要：

Rho/Rock信号通路是调控细胞增殖和组织分化的重要信号通路，也是调节干细胞自我更新过程的信号转导通路。在各种炎症因子的刺激下，通过激酶级联反应，Rho/Rock通路参与了细胞的收缩、趋化、黏附和浸润等生物学行为。Rho/Rock信号转导通路与肺纤维化密切相关，深入了解Rho/Rock通路在肺纤维化中的作用及其机制，有可能为肺纤维化的防治找到新的突破点。

关键词: Rho, Rock, 信号通路, 肺纤维化

Abstract:

Rho/Rock signaling pathway is a key signaling pathway regulating cell proliferation and tissue differentiation, as well as a signal transduction pathway moderating stem cell self-renewal process. Under the stimulation of a various inflammatory cytokines, Rho/Rock pathway is involved in biological behaviors such as cell contraction, chemotaxis, adhesion, and invasion via kinase cascade. Rho/Rock signaling transduction pathway is closely related to pulmonary fibrosis. Therefore, deep understanding of the effects and mechanisms of Rho/Rock pathway in pulmonary fibrosis may reveal novel breaking points for prevention and treatment of pulmonary fibrosis.

Key words: Rho, Rock, pathway, pulmonary fibrosis