上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (8): 1156-.doi: 10.3969/j.issn.1674-8115.2017.08.021

• 综述 • 上一篇    下一篇

双相障碍稳定期执行功能损害的神经影像学研究进展#br#

杨涛，赵国庆，方贻儒，陈俊   

  1. 上海交通大学 医学院附属精神卫生中心心境障碍科，脑科学与技术研究中心，上海 200030
  • 出版日期:2017-08-28 发布日期:2017-09-28
  • 作者简介:杨涛（1988—），女，硕士生；电子信箱：yangtao2015sjtu@foxmail.com
  • 基金资助:
     国家自然科学基金（91232719，81201056，81301159）；上海市卫生系统优秀人才培养项目（XYQ2011014）；上海市科委医学引导类项目 （12401906200）；国家临床重点专科 - 上海市精神卫生中心（卫生部医政司 2011-873）；上海市精神疾病临床医学中心（2014）；科技部“十二五”国家科技支撑 项目（2012BAI01B04）；上海市卫生系统优秀学科带头人培养计划（XBR2013087）；国家高技术研究发展计划“863 计划”（2015AA020509）

Advances in neuroimaging studies on executive impairment of patients with euthymic bipolar disorder#br#

YANG Tao, ZHAO Guo-qing, FANG Yi-ru, CHEN Jun   

  1. Brain Science and Technology Research Center, Depressive Disorders Program, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2017-08-28 Published:2017-09-28
  • Supported by:
     National Natural Science Foundation of China, 91232719, 81201056, 81301159; Excellent Young Talents Program of Shanghai Health System, XYQ2011014; Medicine Guidance Project of Shanghai Committee of Science and Technology, 12401906200; National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH, 2011-873; Shanghai Clinical Center for Mental Disorders, 2014; The “12th Five-year Plan” of National Key Technologies R&D Program, Ministry of Science and Technology of China, 2012BAI01B04; Excellent Academic Leaders Training Plan of Shanghai Health System, XBR2013087; National High-tech R&D Program of China, “863 Program”, 2015AA020509

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摘要：  双相障碍（BD）是一种高复发率、高致残率的慢性精神疾病，认知功能损害是其核心症状之一，并存在于病程的各个阶段。 神经影像学研究发现，大脑体积、白质纤维完整性、关键脑区脑血流信号及血氧饱和度等多是 BD 患者执行功能受损相关因素。该文 就 BD 稳定期患者执行功能损害的大脑结构及功能改变的现状和进展进行综述。

关键词: 双相障碍, 执行功能, 神经影像

Abstract:

Bipolar disorder (BD) is a chronic mental illness with high recurrence rate and disability. As one of the core symptoms, cognitive impairment may occurs at every stage of the disease. Evidence from the neuroimaging studies revealed that the abnormal brain volumes, the blood flow and oxygen saturation of key brain areas are related to executive impairment in patients with bipolar disorder. This article reviews current structural and functional neuroimaging studies about the executive impairment of patients with euthymic bipolar disorder and research progresses.

Key words: bipolar disorder, executive impairment, neuroimaging