上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (7): 825-.doi: 10.3969/j.issn.1674-8115.2018.07.021

• 综述 • 上一篇    下一篇

代谢型谷氨酸受体5与N-甲基-D-天冬氨酸受体的关系及其在疾病中的作用

黄敏，许涛，江伟   

  1. 上海交通大学附属第六人民医院麻醉科，上海 200233
  • 出版日期:2018-07-28 发布日期:2018-07-30
  • 通讯作者: 江伟，电子信箱：jiangw@sjtu.edu.cn。
  • 作者简介:黄敏（1992—），女，博士生；电子信箱：huangmin1224@outlook.com。
  • 基金资助:
    国家自然科学基金（81671083）；上海市科学技术委员会自然基金面上项目（17ZR1421100）

Relationship between metabotropic glutamate receptor 5 and N-methyl-D-aspartate receptor and their roles in diseases

HUANG Min, XU Tao, JIANG Wei   

  1. Department of Anesthesiology, Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2018-07-28 Published:2018-07-30
  • Supported by:
    National Natural Science Foundation of China, 81671083; Natural Foundation of Science and Technology Commission of Shanghai, 17ZR1421100

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摘要： 代谢型谷氨酸受体5（metabotropic glutamate receptor 5，mGluR5）和N-甲基-D-天冬氨酸受体（N-methyl-D-aspartatereceptor，NMDAR）分别属于代谢型和离子型谷氨酸受体家族。近年来，这2类谷氨酸受体在神经及精神类疾病中的研究较受关注。该文主要就2类谷氨酸受体之间的联系及其与疾病关系的最新研究进展进行回顾与总结。

关键词: 代谢型谷氨酸受体5, N-甲基-D-天冬氨酸受体, SH3和多锚蛋白重复结构域3, Homer蛋白

Abstract:

Metabotropic glutamate receptor 5 (mGluR5) and N-methyl-D-aspartatereceptor (NMDAR) belongs to metabotropicandionotropic glutamate receptor family, respectively. In recent years, a lot of attention has been paid to these two types of glutamate receptors in the field of neuroscience and psychiatry. This article mainly summarized the research progress of the relationship between these two kinds of receptors and the influence of their relationship on different diseases.

Key words: metabotropic glutamate receptor 5, N-methyl-D-aspartate receptor, SH3 and multiple ankyrin repeat domains 3, Homer protein

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