上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2026, Vol. 46 ›› Issue (8): 1134-1142.doi: 10.3969/j.issn.1674-8115.2026.08.014

• 论著 · 公共卫生 • 上一篇    

中青年胃肠道癌症化学治疗患者抗逆力的潜在剖面及相关因素分析

王涛1,2, 赵梦晴1, 屈春瑾1, 王琳1()   

  1. 1.上海交通大学护理学院，上海 201318
    2.上海交通大学医学院附属仁济医院护理部，上海 200127
  • 收稿日期:2026-02-27 接受日期:2026-04-14 出版日期:2026-08-28 发布日期:2026-08-28
  • 通讯作者: 王 琳，副教授，博士；电子信箱：wanglsd@shsmu.edu.cn。
  • 作者简介:第一联系人：王涛负责实验设计，王涛、王琳参与论文的写作和修改，赵梦晴、屈春瑾参与论文数据的收集。所有作者均阅读并同意最终稿件的提交。
  • 基金资助:
    上海交通大学医学院科技基金项目(Jyhz2506);上海交通大学医学院护理学科人才队伍建设项目(SJTUHLXK2024)

Analysis of latent profiles and associated factors of resilience among young and middle-aged patients with gastrointestinal cancer undergoing chemotherapy

Wang Tao1,2, Zhao Mengqing1, Qu Chunjin1, Wang Lin1()   

  1. 1.Shanghai Jiao Tong University School of Nursing, Shanghai 201318, China
    2.Nursing Department, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Received:2026-02-27 Accepted:2026-04-14 Online:2026-08-28 Published:2026-08-28
  • Contact: Wang Lin, E-mail: wanglsd@shsmu.edu.cn.
  • About author:First author contact:The study was designed by Wang Tao. The manuscript was drafted and revised by Wang Tao and Wang Lin. Zhao Mengqing and Qu Chunjin participated in the data collection for this study. All authors have read the final version of the manuscript and consented to its submission.
  • Supported by:
    Science and Technology Fund of Shanghai Jiao Tong University School of Medicine(Jyhz2506);Nursing Discipline Talent Team Construction Project of Shanghai Jiao Tong University School of Medicine(SJTUHLXK2024)

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摘要：

目的·探讨中青年胃肠道癌症化学治疗（化疗）患者抗逆力的潜在剖面，并分析剖面归属的相关因素。方法·采用目的抽样法，选取2024年10月—2025年8月在上海交通大学医学院附属仁济医院肿瘤科接受规范化疗的中青年胃肠道癌症患者（18~59岁）作为调查对象。采用一般资料问卷、抗逆力量表、情绪调节问卷、社会支持评定量表、医院焦虑抑郁量表进行横断面调查。采用Mplus 8.3软件进行潜在剖面分析，以抗逆力各条目得分为观测指标，识别中青年胃肠道癌症化疗患者抗逆力的潜在类别。随后以剖面类别为因变量，采用多因素Logistic回归进行相关因素分析。结果·共纳入有效样本393例，患者抗逆力总分为（65.72±13.54）分。模型拟合结果显示3类别模型最优，依据条目得分特征将其分别命名为被动脆弱组（21.4％）、稳健适应组（51.1％）和主动成长组（27.5％）。多因素Logistic回归分析表明：以主动成长组为参照，男性、无宗教信仰、月收入<3 000元、抑郁水平较高、主观支持及认知重评得分较低的患者，更易归入被动脆弱组，无宗教信仰、月收入<10 000元、主观支持及认知重评得分较低的患者，更易归入稳健适应组。结论·中青年胃肠道癌症化疗患者抗逆力存在异质性，可分为被动脆弱组、稳健适应组和主动成长组；男性、无宗教信仰、月收入较低、抑郁水平较高、主观支持较低及认知重评策略使用较少的患者可能抗逆力水平更低。

关键词: 胃肠道癌症, 抗逆力, 中青年, 化学治疗（化疗）, 潜在剖面分析

Abstract:

Objective ·To explore the latent profiles of resilience among young and middle-aged patients with gastrointestinal cancer undergoing chemotherapy, and analyze the factors associated with these profiles. Methods ·From October 2024 to August 2025, a purposive sampling method was adopted to enroll young and middle-aged patients (18‒59 years old) with gastrointestinal cancer who received standardized chemotherapy in the Department of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine. A cross-sectional survey was conducted using the General Information Questionnaire, Resilience Scale, Emotion Regulation Questionnaire, Social Support Rating Scale, and Hospital Anxiety and Depression Scale. Mplus 8.3 software was used for latent profile analysis. With each item score of resilience as the indicator variable, the latent categories of resilience in young and middle-aged patients with gastrointestinal cancer undergoing chemotherapy were identified. Subsequently, multivariate Logistic regression analysis was performed to identify factors associated with the latent profiles, with the profile category as the dependent variable. Results ·A total of 393 valid patients were included, and the total resilience score of patients was 65.72±13.54. The model fitting results showed that the three-profile model was optimal. According to the characteristics of item scores, the three profiles were named as the passive vulnerability group (21.4%), stable adaptation group (51.1%), and active growth group (27.5%). Multivariate Logistic regression analysis revealed that, with the active growth group as the reference, patients who were male, had no religious belief, had a monthly income of less than 3 000 yuan, had a higher depression level, and obtained lower scores of subjective support and cognitive reappraisal were more likely to be classified into the passive vulnerability group. Patients who had no religious belief, had a monthly income of less than 10 000 yuan, and had lower scores of subjective support and cognitive reappraisal were more likely to be classified into the stable adaptation group. Conclusion ·Resilience among young and middle-aged patients with gastrointestinal cancer undergoing chemotherapy exhibits heterogeneity and can be divided into three categories: the passive vulnerable group, stable adaptive group, and active growth group. Patients who are male, have no religious belief, have a lower monthly income, have a higher depression level, have lower subjective support, and use cognitive reappraisal strategies less frequently tend to have lower resilience levels.

Key words: gastrointestinal cancer, resilience, young and middle-aged adult, chemotherapy, latent profile analysis

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