上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (12): 1652-.doi: 10.3969/j.issn.1674-8115.2012.12.027

• 综述 • 上一篇    下一篇

TrkB信号转导通路在肿瘤中的作用

鲍 伟1, 于晓辉2, 万小平1   

  1. 1.上海交通大学 医学院附属国际和平妇幼保健院妇科, 上海 200030； 2.大连市妇产医院妇科, 大连 116033
  • 出版日期:2012-12-28 发布日期:2012-12-31
  • 通讯作者: 万小平, 电子信箱: wanxiaoping61@126.com。
  • 作者简介:鲍 伟（1983—）, 男, 住院医师, 博士；电子信箱: forever_chipper@hotmail.com。

Role of TrkB signal transduction pathway in tumors

BAO Wei1, YU Xiao-hui2, WAN Xiao-ping1   

  1. 1.Department of Gynecology, International Peace Maternity and Child Health Hospital of China Welfare Institute, Shanghai 200030, China；2.Department of Gynecology, Dalian Obstetrics and Gynecology Hospital, Dalian 116033, China
  • Online:2012-12-28 Published:2012-12-31

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摘要：

神经营养因子－酪氨酸激酶受体（NT-Trk）信号通路在神经细胞的发育、生长中发挥重要的调控作用。近年来发现Trk还参与了许多恶性肿瘤的发病机制。研究认为TrkB表达与肿瘤生成有关，脑源性生长因子（BDNF）/TrkB信号转导通路激活赋予肿瘤存活、血管生成、化疗耐药和失巢凋亡抑制能力。该文就TrkB信号转导通路在肿瘤中的作用作一综述。

关键词: 神经营养因子, 酪氨酸激酶受体, 脑源性神经营养因子, 失巢凋亡抑制, Trk抑制剂

Abstract:

Neurotrophin-tyrosine kinase receptor (NT-Trk) signaling pathway plays an important role in the neural regulation of development. Now it has been recently revealed that Trk may also participate in the pathogenesis of many malignant tumors. It is demonstrated that the expression of TrkB is related to oncogenesis. The activation of brain-derived neurotrophic factor (BDNF)/TrkB signal transduction pathway stimulates tumor cell survival and angiogenesis, and contributes to the resistance to cytotoxic drugs and anoikis. The role of TrkB signal transduction pathway in tumors is reviewed in this paper.

Key words: neurotrophin, tyrosine kinase receptor, brain-derived neurotrophic factor, anoikis resistance, Trk inhibitors