综述

长链非编码RNA调控神经干细胞分化的研究进展

  • 胡国文 ,
  • 周 翔 ,
  • 汪 泱 ,
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  • 1.南昌大学 第二附属医院神经外科, 南昌 330006; 2.上海交通大学附属第六人民医院四肢显微外科研究所, 上海 200233; 3.上海交通大学附属第六人民医院神经外科, 上海 200233
胡国文(1991—), 男, 硕士生; 电子信箱: hugw0625@163.com。

网络出版日期: 2014-08-11

基金资助

国家自然科学基金(81272170)

Advances of differentiation of neural stem cells regulated by long non-coding RNAs

  • HU Guo-wen ,
  • ZHOU Xiang ,
  • WANG Yang ,
  • et al
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  • 1.Department of Neurosurgery, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China; 2.Institute for Microsurgery of Extremities, the Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China; 3.Department of Neurosurgery, the Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

Online published: 2014-08-11

Supported by

National Nature Science Foundation of China,81272170

摘要

长链非编码RNAs (lncRNA)是一类转录本长度在200至数千个核苷酸且不表现任何蛋白质编码潜能的非编码RNAs (ncRNA),它是ncRNAs家族中最大的一类。多项研究表明lncRNAs可以通过一系列机制在表观遗传水平、转录水平及转录后水平对基因表达进行调控。而越来越多的研究发现lncRNAs在中枢神经系统的发育中起着重要的作用。某些类型的lncRNAs可以调控神经干细胞(NSCs)定向分化为神经元,而另外一些类型的lncRNAs可以调控NSCs向胶质细胞分化。文章就lncRNAs调控NSCs分化的研究新进展进行综述,以期为研究神经系统发育提供新的思路。

本文引用格式

胡国文 , 周 翔 , 汪 泱 , . 长链非编码RNA调控神经干细胞分化的研究进展[J]. 上海交通大学学报(医学版), 2014 , 34(7) : 1087 . DOI: 10.3969/j.issn.1674-8115.2014.07.026

Abstract

Long non-coding RNAs (lncRNA) is the largest class of ncRNAs with a transcript length from 200 to several thousand nucleotides and have no known proteincoding potential. LncRNAs can regulate the gene expression at epigenetic, transcriptional, and post-transcriptional levels through a wide range of mechanisms. More and more studies suggest that lncRNAs play a critical role in the development of central nervous system. Some types of lncRNAs can regulate the differentiation of neural stem cells (NSCs) towards neuronal lineages, while other types of lncRNAs can regulate the differentiation of NSCs towards neuroglia lineages. This paper reviews the latest progresses of studies on the differentiation of NSCs regulated by lncRNAs and provides new ideas for exploring the development of the nerve system.

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