目的研究强迫症（OCD）患者的反应抑制功能改变及其与行为抑制/激活系统活动水平的相关性。方法以45例OCD患者为研究对象，49名健康者为对照。采用信号停止任务(SST)检测反应抑制功能，进行包括行为抑制/激活系统量表在内的心理评估，比较组间差异。结果①SST：OCD组的停止信号反应时间[（351.16±48.18） ms]较对照组[（389.65±30.47） ms]明显缩短（P<0.01），OCD组对Go信号的正确反应率为（75.67±15.70）%，较对照组（86.45±10.23）%显著降低（P<0.01）。②行为抑制/激活系统量表：OCD组的行为抑制系统维度得分为11.53±2.86，较对照组（9.39±3.32）显著增高（P<0.01），两组行为激活系统维度得分的差异无统计学意义（P>0.05）。③OCD组中高反应抑制组的行为抑制系统维度得分显著高于一般反应抑制组和对照组（P<0.05）。结论OCD患者反应抑制功能增强，且受到行为抑制系统活跃程度影响。

ObjectiveTo investigate the changes of response inhibition function of patients with obsessive-compulsive disorder (OCD) and its correlation with the activity of behavioral inhibition system/behavioral activation system (BIS/BAS).MethodsA total of 45 patients with OCD and 49 healthy controls were enrolled. The response inhibition function was assessed by the stop signal task (SST). BIS/BAS scale was used to perform the psychological assessment and the differences between two groups were compared.Results①SST: the stop signal reaction time (SSRT) of the OCD group [(351.16±48.18) ms] was significantly shorter than that of the control group [(389.65±30.47) ms](P<0.01). The rates of go success (GS) of the OCD group [(75.67±15.70)%] were significantly lower than those of the control group ([86.45±10.23)%](P<0.01). ②BIS/BAS scale: the scores of BIS of the OCD group (11.53±2.86) were significantly higher than those of the control group (9.39±3.32) (P<0.01). The difference of scores of BAS between two groups were not statistically significant (P>0.05). ③The scores of BIS of OCD patients with better response inhibtion function were significantly higher than those of other patients and controls (P<0.05).ConclusionThe response inhibition function of patients with OCD is enhanced and affected by the activity of BIS.