上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2015, Vol. 35 ›› Issue (10): 1502-.doi: 10.3969/j.issn.1674-8115.2015.10.014

• 论著（临床研究） • 上一篇    下一篇

#br# 强迫症患者反应抑制功能与行为抑制/激活系统的关系

王渊，王振，张海音，陈珏，赵青，肖泽萍   

  1. 上海交通大学 医学院附属精神卫生中心， 上海200030
  • 出版日期:2015-10-20 发布日期:2015-12-22
  • 通讯作者: 肖泽萍, 电子信箱: xiaozeping88@163.com; 王振, 电子信箱: wangzhen@smhc.org.cn
  • 作者简介: 王渊（1988—）， 女， 住院医师， 博士; 电子信箱: wangyuan19881006@live.cn
  • 基金资助:

     上海市科委医学引导类项目（124119a8601）；上海交通大学“医工交叉研究基金”（YG2013MS65）；国家临床重点专科-上海市精神卫生中心（卫生部医政司2011-873）

Correlation between response inhibition function and behavioral inhibition/activation systems of patients with obsessive-compulsive disorder

WANG Yuan, WANG Zhen, ZHANG Hai-yin, CHEN Jue, ZHAO Qing, XIAO Ze-ping   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai200030， China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    Medicine Guidance Project of Science and Technology Commission of Shanghai Municipality, 124119a8601； Biomedical Engineering Cross Research Foundation of Shanghai Jiao Tong University, YG2013MS65； The National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH 2011-873

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摘要：

目的研究强迫症（OCD）患者的反应抑制功能改变及其与行为抑制/激活系统活动水平的相关性。方法以45例OCD患者为研究对象，49名健康者为对照。采用信号停止任务(SST)检测反应抑制功能，进行包括行为抑制/激活系统量表在内的心理评估，比较组间差异。结果①SST：OCD组的停止信号反应时间[（351.16±48.18） ms]较对照组[（389.65±30.47） ms]明显缩短（P<0.01），OCD组对Go信号的正确反应率为（75.67±15.70）%，较对照组（86.45±10.23）%显著降低（P<0.01）。②行为抑制/激活系统量表：OCD组的行为抑制系统维度得分为11.53±2.86，较对照组（9.39±3.32）显著增高（P<0.01），两组行为激活系统维度得分的差异无统计学意义（P>0.05）。③OCD组中高反应抑制组的行为抑制系统维度得分显著高于一般反应抑制组和对照组（P<0.05）。结论OCD患者反应抑制功能增强，且受到行为抑制系统活跃程度影响。

关键词: 强迫症, 行为抑制系统, 行为激活系统, 信号停止任务

Abstract:

ObjectiveTo investigate the changes of response inhibition function of patients with obsessive-compulsive disorder (OCD) and its correlation with the activity of behavioral inhibition system/behavioral activation system (BIS/BAS).MethodsA total of 45 patients with OCD and 49 healthy controls were enrolled. The response inhibition function was assessed by the stop signal task (SST). BIS/BAS scale was used to perform the psychological assessment and the differences between two groups were compared.Results①SST: the stop signal reaction time (SSRT) of the OCD group [(351.16±48.18) ms] was significantly shorter than that of the control group [(389.65±30.47) ms](P<0.01). The rates of go success (GS) of the OCD group [(75.67±15.70)%] were significantly lower than those of the control group ([86.45±10.23)%](P<0.01). ②BIS/BAS scale: the scores of BIS of the OCD group (11.53±2.86) were significantly higher than those of the control group (9.39±3.32) (P<0.01). The difference of scores of BAS between two groups were not statistically significant (P>0.05). ③The scores of BIS of OCD patients with better response inhibtion function were significantly higher than those of other patients and controls (P<0.05).ConclusionThe response inhibition function of patients with OCD is enhanced and affected by the activity of BIS.

Key words: obsessive-compulsive disorder, behavioral inhibition system, behavioral activation system, stop signal task