综述

核素细胞凋亡显像剂的研究进展

  • 刘秋芳 ,
  • 宋少莉
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  • 上海交通大学 医学院附属仁济医院核医学科, 上海 200127
刘秋芳(1991—), 女, 硕士生; 电子信箱: liuqiufang819@163.com。

网络出版日期: 2016-01-13

基金资助

国家自然科学基金(81101073,81471708);上海交通大学医工(理)交叉研究基金(YG2012MS13)

Advances of radionuclide imaging for cell apoptosis

  • LIU Qiu-fang ,
  • SONG Shao-li
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  • Department of Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

Online published: 2016-01-13

Supported by

National Natural Science Foundation of China, 81101073, 81471708; Biomedical Engineering Cross Research Foundation of Shanghai Jiao Tong University, YG2012MS13

摘要

放射性核素细胞凋亡显像具有直观、无创伤和实时在体观察细胞凋亡等特点,在脑及心肌细胞缺血再灌注损伤的观察、器官移植后排斥反应的检测、肿瘤放疗和化疗效果的评估等方面具有较好应用前景。本文主要根据临床前期的研究对放射性核素凋亡显像剂的设计、作用机制及应用进行介绍。

本文引用格式

刘秋芳 , 宋少莉 . 核素细胞凋亡显像剂的研究进展[J]. 上海交通大学学报(医学版), 2015 , 35(11) : 1743 . DOI: 10.3969/j.issn.1674-8115.2015.11.029

Abstract

Radionuclide imaging for the cell apoptosis is a direct, noninvasive, and real-time imaging technique. It is a hopeful method for observing brain and myocardial ischemic reperfusion injury, detecting allograft rejection, and evaluating the effects of tumor chemotherapy and radiotherapy. This paper introduces the design, mechanisms, and applications of radionuclide agents based on preclinical studies.

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