胰岛β细胞定量检测的分子影像学研究进展
网络出版日期: 2016-02-26
基金资助
国家自然科学基金(81171367, 81471688)
Advances of quantitative detection of islet β-cells by molecular imaging
Online published: 2016-02-26
Supported by
National Natural Science Foundation of China, 81171367, 81471688。
琚卉君 , 潘昱 , 张一帆 . 胰岛β细胞定量检测的分子影像学研究进展[J]. 上海交通大学学报(医学版), 2016 , 36(1) : 119 . DOI: 10.3969/j.issn.1674-8115.2016.01.024
Type 1 and type 2 diabetes are caused by the destruction of pancreatic islet β cells or the reduction of their function and mass (β-cell mass, BCM). Therefore, early detection of BCM is vital for the diagnosis and treatment of diabetes. The molecular imaging methods are an important way to detect BCM, mainly including optical imaging, magnetic resonance imaging (MRI), radionuclide imaging, etc. In recent years, specific imaging of islet β cells by utilizing the radionuclide-labelled glucagon-like peptide-1 (GLP-1) and its analogues has achieved remarkable achievements. This paper reviews novel molecular imaging methods for the detection of islet BCM.
Key words: diabetes; islet cells; molecular imaging; glucagon-like peptide-1
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