上海交通大学学报（医学版）

上海交通大学学报（医学版）

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胰岛β细胞定量检测的分子影像学研究进展

琚卉君,潘昱,张一帆   

  1. 上海交通大学 医学院附属瑞金医院核医学科, 上海 200025
  • 出版日期:2016-01-28 发布日期:2016-02-26
  • 通讯作者: 张一帆, 电子信箱: zhang_yifan@126.com。
  • 作者简介:琚卉君 (1991—)， 女， 博士生; 电子信箱: juhuijun@hotmail.com。
  • 基金资助:

    国家自然科学基金(81171367, 81471688)

Advances of quantitative detection of islet β-cells by molecular imaging

JU Hui-jun, PAN Yu, ZHANG Yi-fan   

  1. Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2016-01-28 Published:2016-02-26
  • Supported by:

    National Natural Science Foundation of China, 81171367, 81471688。

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摘要：

1型和2型糖尿病是由胰岛β细胞的破坏或其功能减退及数量（BCM）减少所致，因此早期检测BCM对糖尿病的诊断和治疗具有重要的价值。分子影像学方法是检测BCM的重要方法，主要包括光学显像、磁共振成像（MRI）、核素显像等。近年来，利用核素标记胰高血糖素样肽1(GLP-1)及其类似物进行胰岛β细胞特异性显像取得了显著成效，为胰岛BCM的检测提供了崭新的分子影像方法，该文就此作一综述。

关键词: 糖尿病, 胰岛细胞, 分子影像, 胰高血糖素样肽1

Abstract:

Type 1 and type 2 diabetes are caused by the destruction of pancreatic islet β cells or the reduction of their function and mass (β-cell mass, BCM). Therefore, early detection of BCM is vital for the diagnosis and treatment of diabetes. The molecular imaging methods are an important way to detect BCM, mainly including optical imaging, magnetic resonance imaging (MRI), radionuclide imaging, etc. In recent years, specific imaging of islet β cells by utilizing the radionuclide-labelled glucagon-like peptide-1 (GLP-1) and its analogues has achieved remarkable achievements. This paper reviews novel molecular imaging methods for the detection of islet BCM.

Key words: diabetes, islet cells, molecular imaging, glucagon-like peptide-1