糖尿病胃轻瘫的发病机制、诊断和治疗研究进展
网络出版日期: 2016-05-26
基金资助
上海市卫生局基金(20124273);上海市科委基金(14441903502);上海交通大学医学院科技基金(12XJ10015)
Research progresses in pathogenesis, diagnosis, and treatment of diabetic gastroparesis
Online published: 2016-05-26
Supported by
Shanghai Municipal Health Bureau, 20124273; Science and Technology Commission of Shanghai Municipality,14441903502; Shanghai Jiao Tong University School of Medicine, Science and Technology Fund,12XJ10015
冯日露 , 麻静 . 糖尿病胃轻瘫的发病机制、诊断和治疗研究进展[J]. 上海交通大学学报(医学版), 2016 , 36(5) : 761 . DOI: 10.3969/j.issn.1674-8115.2016.05.029
Diabetic gastroparesis (DGP) is characterized by delayed gastric emptying in patients with prolonged type 1 and type 2 diabetes mellitus. Common symptoms include nausea, vomiting, bloating, and epigastric pain. Gastroparesis results in malnutrition, impaired drug absorption, and disordered glycaemic control and affects the quality of life. The clinical management of diabetic gastroparesis is not ideal due to unclear pathogenesis and the ignorance of changes in gastric motility. It has been recognized that autonomic neuropathy and hyperglyaemia are main contributors to the gastrointestinal dysfunction in diabetic patients. Therefore, current treatments mainly relieve gastrointestinal symptoms and control the blood sugar. Combining with progresses of intestinal motility research in recent years, this paper reviews the pathogenesis, diagnosis, and treatment of diabetic gastroparesis.
Key words: gastroparesis; hyperglycaemia; glucagon-like peptide-1; diabetes mellitus
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