尽管肿瘤糖代谢重编程受到越来越多的关注，但其具体调控机制尚未明确。蛋白质组学研究揭示了大量胞质与线粒体蛋白存在翻译后赖氨酸残基的修饰，提示其在代谢调控过程中具有重要意义。该文主要总结了蛋白质翻译后赖氨酸修饰在肿瘤糖代谢调控中的作用，进一步阐明蛋白质翻译后修饰与肿瘤糖代谢调控之间的关系，有望为肿瘤提供治疗的新思路。

Although reprogramming of cancer glucose metabolism has attracted more and more attention, the underlying mechanism is not clear. Proteomic studies revealed that post-translational modifications (PTMs) of lysine residues exist in numerous cytoplasmic and mitochondrial proteins, suggesting they play a critical role in metabolic regulation. The present review summarizes the role of protein PTMs of lysine in the regulation of tumor glucose metabolism and further elucidates the association between PTMs and the regulation of tumor glucose metabolism, which may provide novel approaches to tumor treatment.