上海交通大学学报（医学版）

上海交通大学学报（医学版）

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肿瘤糖代谢途径中蛋白质翻译后赖氨酸修饰的作用

王韵茜 陈萦晅   

  1. 上海交通大学 医学院附属仁济医院消化内科，上海市消化疾病研究所，上海 200001
  • 出版日期:2016-08-29 发布日期:2016-08-31
  • 通讯作者: 陈萦晅，电子信箱：yingxuanchen71@sjtu.edu.cn。
  • 作者简介:王韵茜（1989—），女，硕士生；电子信箱：wangyunqian0788@163.com。
  • 基金资助:

    国家自然科学基金（81572303）；上海市教育委员会高峰高原学科建设计划（20152210）

Role of protein post-translational modifications of lysine in tumor glucose metabolism

WANG Yun-qian, CHEN Ying-xuan   

  1. Shanghai Institute of Digestive Disease, Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200001, China
  • Online:2016-08-29 Published:2016-08-31
  • Supported by:

    National Natural Science Foundation of China, 81572303；Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152210

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摘要：

尽管肿瘤糖代谢重编程受到越来越多的关注，但其具体调控机制尚未明确。蛋白质组学研究揭示了大量胞质与线粒体蛋白存在翻译后赖氨酸残基的修饰，提示其在代谢调控过程中具有重要意义。该文主要总结了蛋白质翻译后赖氨酸修饰在肿瘤糖代谢调控中的作用，进一步阐明蛋白质翻译后修饰与肿瘤糖代谢调控之间的关系，有望为肿瘤提供治疗的新思路。

关键词: 肿瘤, 赖氨酸, 代谢, 翻译后修饰

Abstract:

Although reprogramming of cancer glucose metabolism has attracted more and more attention, the underlying mechanism is not clear. Proteomic studies revealed that post-translational modifications (PTMs) of lysine residues exist in numerous cytoplasmic and mitochondrial proteins, suggesting they play a critical role in metabolic regulation. The present review summarizes the role of protein PTMs of lysine in the regulation of tumor glucose metabolism and further elucidates the association between PTMs and the regulation of tumor glucose metabolism, which may provide novel approaches to tumor treatment.

Key words: cancer, lysine, metabolism, post-translational modifications