综述

转录因子AP-2与胚胎发育及心脏血管发育研究进展

  • 王静 ,
  • 李奋
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  • 上海交通大学 医学院附属上海儿童医学中心心内科,上海 200127
王静(1983—),女,住院医师,硕士;电子信箱:tie119@126.com。

网络出版日期: 2016-11-29

基金资助

国家自然科学基金(81170152)

Research advances in transcription factor AP-2 in embryonic and cardiovascular development
 

  • WANG Jing ,
  • LI Fen
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  • Department of Pediatric Cardiology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

Online published: 2016-11-29

Supported by

National Natural Science Foundation of China, 81170152

摘要

转录因子AP-2家族在胚胎发育及心脏血管发育过程中均发挥着重要作用,常导致胚胎发育受阻。心脏血管发育主要与AP-2α及AP-2β两者相关,其中AP-2α主要作用于心室流出道及大动脉,而AP-2β被证实与心脏动脉导管的开放与闭合机制有关。该文系统综述了AP-2基因家族的结构、表达、在胚胎发育及心脏血管发育中的功能与途径,尤其是在动脉导管未闭发生中的最新研究进展。

本文引用格式

王静 , 李奋 . 转录因子AP-2与胚胎发育及心脏血管发育研究进展[J]. 上海交通大学学报(医学版), 2016 , 36(11) : 1658 . DOI: 10.3969/j.issn.1674-8115.2016.11.024

Abstract

Transcription factor AP-2 plays an important role in embryonic and cardiovascular development and often influences the development of embryo. AP-2α and AP-2β are associated with the development of cardiovascular system. AP-2α mainly affects ventricular outflow tract and arteries, while AP-2β has been identified to be involved in the opening and closing of ductus arterious. This paper systematically reviews latest research advances in the structure and expression of AP-2 gene family, as well as its functions and mechanisms in embryonic and cardiovascular development, especially in patent ductus arterious.

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