网络出版日期: 2016-11-29
基金资助
国家自然科学基金(81170152)
Online published: 2016-11-29
Supported by
National Natural Science Foundation of China, 81170152
王静 , 李奋 . 转录因子AP-2与胚胎发育及心脏血管发育研究进展[J]. 上海交通大学学报(医学版), 2016 , 36(11) : 1658 . DOI: 10.3969/j.issn.1674-8115.2016.11.024
Transcription factor AP-2 plays an important role in embryonic and cardiovascular development and often influences the development of embryo. AP-2α and AP-2β are associated with the development of cardiovascular system. AP-2α mainly affects ventricular outflow tract and arteries, while AP-2β has been identified to be involved in the opening and closing of ductus arterious. This paper systematically reviews latest research advances in the structure and expression of AP-2 gene family, as well as its functions and mechanisms in embryonic and cardiovascular development, especially in patent ductus arterious.
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