目的 ·研究上海市青少年学生中抑郁情绪对烟草使用的影响，为制定有效的青少年控烟措施提供参考。方法 ·采用分层随机整群抽样法调查了上海市 10 557名学生，使用世界卫生组织的全球青少年烟草调查问卷和患者健康问卷 2 条目中文版进行调查。结果 ·调查对象具有抑郁情绪的比例为 12.4%，抑郁情绪者现在吸烟率（ 8.0% vs 2.5%）和未来吸烟意向（ 14.2% vs 4.6%）均高于无抑郁情绪者（ P0.000）。与无抑郁情绪者相比，抑郁情绪者现在吸烟风险为 1.56倍（95% CI 1.16～ 2.10），未来 1年吸烟风险为 1.92倍（95% CI 1.54～ 2.40），且具有抑郁情绪的女生现在吸烟风险高于男生，初中生高于高中生。结论 ·抑郁情绪是青少年学生烟草使用的影响因素之一；学校及社会需重视青少年的心理健康维护，积极开展以学校为基础的预防措施，尤其需关注女生及初中生等高危人群。

Objective · To study the impact of depression on tobacco among adolescents in Shanghai, and to provide reference for the development of effective youth tobacco control measures. Methods · A stratified random cluster sampling method was used to extract 10 557 middle school students in Shanghai. The survey was conducted using the Global Youth Tobacco Questionnaire (WHO) and the Patient Health Questionnaire 2-Item Chinese Version (PHQ-2). Results · Among the respondents, the incidence of depression motion was 12.4%. Both the current smoking rate (8.0% vs 2.5%) and future smoking intention (14.2% vs 4.6%) among students with depression were higher than those without depression (P0.000). Compared with those without depression, the risks of current smoking and future smoking intention among youth with depression were 1.56 times (95% CI 1.16-2.10) and 1.92 times (95% CI 1.54-2.40) respectively. In addition, the risk of smoking behavior was higher among female with depression than male students, as well as junior high school students than senior high school students. Conclusion · Depression is one of the influencing factors of tobacco in adolescents. Schools and society should attach importance to the mental health maintenance of adolescents, carry out school-based preventive measures actively, and pay attention to high-risk groups such as female and junior school students with depression particularly.