目的 ·比较月经相关性偏头痛患者与非月经性偏头痛患者维生素 D水平的差异。方法 ·纳入 2017年 6月— 2018年 6月于上海交通大学附属仁济医院就诊的符合月经相关性偏头痛患者 100例为病例组，匹配 100例非月经性偏头痛患者为对照组。采集患者临床信息及检测血清维生素 D水平。采用单因素分析比较组间临床资料的差异，采用 Logistic回归模型分析月经相关性偏头痛与维生素 D水平的关系。结果 ·与对照组相比，病例组维生素 D水平较低 [（13.48±5.02）ng/mL vs（14.93±4.94）ng/mL]，组间差异有统计学意义（ P0.042）。其余临床资料的组间差异均无统计学意义（均 P>0.05）。Logistic回归分析结果显示，维生素 D低于 10 ng/mL的患者是高于 20 ng/mL的患者发生月经相关性偏头痛的 3.656倍（OR3.656，95%CI 1.382～ 9.672，P0.009）。另外，偏头痛发生于月经前与月经中的患者在临床特点及维生素 D水平等方面的差异均无统计学意义（均 P>0.05）。结论 ·低维生素 D水平可能与月经相关性偏头痛发生相关，但与偏头痛发生于月经前或月经中无关。

Objective · To compare vitamin D levels in the patients with menstrually related migraine and those with non-menstrual migraine. Methods · A total of 100 patients with menstrually related migraine were enrolled as case group, and 100 patients with non-menstrual migraine were matched as control group in Renji Hospital, Shanghai Jiao Tong University School of Medicine, June 2017 to June 2018. The patients’ information was collected and serum vitamin D levels were measured. Univariate analysis was performed to analyze the differences between the groups, and Logistic regression model was performed to analyze the relationship between menstrually related migraine and vitamin D levels. Results · Vitamin D levels were lower in case group than those in control group [(13.48±5.02) ng/mL vs (14.93±4.94) ng/mL, P0.042]. There were no statistically significant differences in other indexes between the groups (P>0.05). Logistic regression analysis showed that the patients with vitamin D less than 10 ng/mL were more likely to have menstrually related migraine than those with vitamin D more than 20 ng/ml (OR3.656, 95% CI 1.382-9.672，P0.009). In addition, there were no statistically significant differences in clinical characteristics and vitamin D levels between the patients with migraine occurring in premenstrual period and menstrual period (P>0.05). Conclusion · Low vitamin D levels may be associated with menstrually related migraine, but not with its occurrence in premenstrual or menstrual period. [Key words]migraine; menstrually related; vitamin D