N6-腺苷酸甲基化（N6-methyladenosine，m6A）是真核细胞中最常见、最丰富的信使RNA（message RNA，mRNA）内部修饰，在甲基转移酶和去甲基酶的作用下，形成一种动态、可逆的甲基化过程，参与多种细胞基因表达调控与生物学过程。近年来，研究发现m6A修饰在免疫细胞分化与调控功能中具有重要作用，这为免疫系统相关性疾病的研究和治疗提供了新思路。文章就近年来m6A 修饰在免疫调控中的作用相关研究进展作一综述。

N6-methyladenosine (m6A) is the most prevalent and abundant post-transcriptional RNA modification in eukaryotes. m6A is a dynamic and reversible process catalyzedm6A methyltransferase complex and demethylase. m6A is involved in the regulations of gene and biological processes. Recently, researches have discovered that m6A plays a vital role in the differentiation and regulation of immune cells, which could provide a new idea for the research and therapy of immune-related diseases. The present article reviews the recent progresses of m6A in immunoregulation.