上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2022 , Vol. 42 >Issue 1: 113 - 118

DOI: https://doi.org/10.3969/j.issn.1674-8115.2022.01.017

综述

A型肉毒毒素治疗神经源性膀胱的研究进展

  • 张霖 ,
  • 陈忠
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  • 上海交通大学附属第六人民医院泌尿外科，上海 200233
张霖（1995—），男，硕士生；电子信箱：colin201108@163.com。
陈忠，电子信箱：csy2000777@sina.com。

收稿日期: 2021-07-27

  网络出版日期: 2022-01-28

基金资助

上海市卫生和计划生育委员会面上项目(20174011)

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Research progress of botulinum toxin A in treatment of neurogenic bladder

  • Lin ZHANG ,
  • Zhong CHEN
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  • Department of Urology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
CHEN Zhong, E-mail: csy2000777@sina.com.

Received date: 2021-07-27

  Online published: 2022-01-28

Supported by

Project of Shanghai Municipal Commission of Health and Family Planning(20174011)

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摘要

近年来，逼尿肌内注射A型肉毒毒素（botulinum toxin A，BTX-A）治疗神经源性膀胱取得了良好的治疗效果，不仅能改善膀胱功能，而且能减轻下尿路症状，提高患者的生活质量。此外，该项技术具有微创、不良反应轻、可重复注射的优点。目前，国际上对于BTX-A的注射方案并没有达成共识。该文根据近年来的研究成果，对BTX-A的作用机制、类型、注射方案、治疗效果、影响疗效的因素以及不良反应和禁忌证做一综述，为BTX-A在临床中的应用提供参考。

关键词： A型肉毒毒素; 神经源性膀胱; 神经源性逼尿肌过度活动

本文引用格式

张霖 , 陈忠 . A型肉毒毒素治疗神经源性膀胱的研究进展[J]. 上海交通大学学报（医学版）, 2022 , 42(1) : 113 -118 . DOI: 10.3969/j.issn.1674-8115.2022.01.017

Abstract

In recent years, intradetrusor injection of botulinum toxin A (BTX-A) has achieved satisfactory therapeutic effects on the treatment of neurogenic bladder, improving the bladder function and reducing the lower urinary tract symptoms while improving patients' quality of life. In addition, this therapy has advantages including minimal invasiveness, mild side effects, and allowing repeated injections. At present, there is no international consensus on the injection plan for BTX-A. Therefore, based on the recent clinical research results, this paper reviews the mechanism of action, types, usage, therapeutic effects, influencing factors, as well as adverse reactions and contraindications of BTX-A, in an attempt to provide evidence for its clinical application.

Key words： botulinum toxin A; neurogenic bladder; neurogenic detrusor overactivity

参考文献

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