收稿日期: 2021-06-24
网络出版日期: 2022-01-28
基金资助
上海交通大学医学院科技基金(Jyh1903);上海市第一人民医院护理学院级课题(02.06.01.19.46);2020年上海市“医苑新星”人才计划
Influences of oral administration of probiotics on postoperative infection and liver function recovery in patients with partial hepatectomy
Received date: 2021-06-24
Online published: 2022-01-28
Supported by
Science and Technology Fund of Shanghai Jiao Tong University School of Medicine(Jyh1903);Nursing Project of Shanghai General Hospital(02.06.01.19.46);Shanghai “Rising Stars of Medical Talent” Program(2020)
目的·探讨口服益生菌对肝部分切除术患者术后感染和肝功能恢复的影响。方法·入组上海交通大学附属第一人民医院165例行肝部分切除术的患者，应用随机数字表将患者分为传统机械性肠道准备组（MBP组，n=55）、无肠道准备组（NBP组，n=55）和益生菌肠道准备组（PBP组，n=55）。收集患者临床资料，包括基本信息，术后发热情况，排气排便时间，术后第1、3、5日感染指标和肝功能指标，并进行组间比较。结果·3组患者基本资料比较，差异均无统计学意义（均P>0.05）。术后第5日，PBP组患者白细胞计数显著低于MBP组（P=0.012）和NBP组（P=0.029）。术后第3日、第5日PBP组谷丙转氨酶水平较MBP组和NBP组显著降低（术后第3日：P=0.040，P=0.036。术后第5日：P=0.002，P=0.019）。结论·口服益生菌肠道准备有助于减轻肝部分切除术后感染，加快肝功能恢复。
吴懿 , 方芳 , 黄浩 , 陈瑛 . 口服益生菌对肝部分切除术患者术后感染和肝功能恢复的影响[J]. 上海交通大学学报（医学版）, 2022 , 42(1) : 9 -15 . DOI: 10.3969/j.issn.1674-8115.2022.01.002
·To investigate the influences of oral administration of probiotics on postoperative infection and liver function recovery in patients with partial hepatectomy.
·A total of 165 patients undergoing partial hepatectomy in Shanghai General Hospital, Shanghai Jiao Tong University, were involved in this prospective randomized control study. In accordance with the random number table, patients were divided into mechanical bowel preparation group (MBP group, n=55), non-bowel preparation group (NBP group, n=55) and probiotics bowel preparation group (PBP group, n=55). Patients' general information, postoperative fever, the first time of flatus and defecation, and infectious indexes and liver function indexes on the 1st,3rd and 5th day after operation were collected and compared among the groups.
·There was no significant difference in the basic data among the 3 groups (all P>0.05). On the 5th day after operation, the white blood count of the PBP group was significantly lower than that of the MBP group (P=0.012) and NBP group (P=0.029). The level of glutamic-pyruvic transaminase of the PBP group was significantly lower than that of the MBP group and NBP group on the 3rd day (P=0.040, P=0.036) and the 5th day (P=0.002, P=0.019) after operation.
·Oral probiotics intestinal preparation is helpful to reduce infection after partial hepatectomy and accelerate the recovery of liver function.
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