上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2022 , Vol. 42 >Issue 2: 247 - 252

DOI: https://doi.org/10.3969/j.issn.1674-8115.2022.02.018

综述

桥粒黏蛋白2在消化系统肿瘤中的功能研究进展

  • 李彦庆 ,
  • 王晓霞 ,
  • 贾向东 ,
  • 任猛 ,
  • 许天祥
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  • 1.内蒙古科技大学包头医学院研究生院，包头 014000
    2.内蒙古自治区人民医院重症医学科，呼和浩特 010017
    3.内蒙古自治区人民医院肿瘤中心腹部肿瘤外科，呼和浩特 010017
李彦庆 (1995—)，男，硕士生；电子信箱：825154971@qq.com。
许天祥，电子信箱：122784509@qq.com。

收稿日期: 2021-09-25

  网络出版日期: 2022-03-17

基金资助

内蒙古自治区自然科学基金(2019MS08085);内蒙古自治区人民医院博士科研启动资金(2020BS06);卫生健康科技计划项目(202201012)

收起

Research progress in the function of desmoglein-2 in digestive system tumors

  • Yanqing LI ,
  • Xiaoxia WANG ,
  • Xiangdong JIA ,
  • Meng REN ,
  • Tianxiang XU
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  • 1.Graduate School of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014000, China
    2.Intensive Care Unit, Inner Mongolia People's Hospital, Hohhot 010017, China
    3.Abdominal Tumor Surgery, Center of Tumor, Inner Mongolia People's Hospital, Hohhot 010017, China
XU Tianxiang, E-mail:122784509@qq.com.

Received date: 2021-09-25

  Online published: 2022-03-17

Supported by

Natural Science Foundation of Inner Mongolia Autonomous Region(2019MS08085);Start Up Fund for Doctoral Research of People's Hospital of Inner Mongolia Autonomous Region(2020BS06);Health Science and Technology Planning Project(202201012)

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摘要

桥粒黏蛋白2（desmoglein-2，DSG2）是钙黏着蛋白家族成员之一，作为桥粒的重要组成部分，主要起维持细胞间黏附的作用。研究发现，DSG2还可以通过信号转导调控细胞的增殖、分化和凋亡，在调节肠上皮屏障中也发挥着关键作用。随着研究的深入，越来越多的证据表明DSG2在多种消化系统肿瘤中表达异常，表达水平各有不同，而表达水平与肿瘤的预后密切相关，推测DSG2在不同的消化系统肿瘤的发生和发展中发挥不同的作用。该文就DSG2的生物学功能及其在消化系统肿瘤中的作用进行综述。

关键词： 桥粒黏蛋白2; 消化系统肿瘤; 生物学功能

本文引用格式

李彦庆 , 王晓霞 , 贾向东 , 任猛 , 许天祥 . 桥粒黏蛋白2在消化系统肿瘤中的功能研究进展[J]. 上海交通大学学报（医学版）, 2022 , 42(2) : 247 -252 . DOI: 10.3969/j.issn.1674-8115.2022.02.018

Abstract

Desmoglein-2 (DSG2) is a member of the cadherin family. As an important part of desmoglein, DSG2 mainly plays a role in maintaining intercellular adhesion. Studies have found that DSG2 can also regulate cell proliferation, differentiation and apoptosis through signal transduction, and plays a key role in regulating intestinal epithelial barrier. With the deepening of research, more and more evidence shows that DSG2 is abnormally expressed in a variety of digestive system tumors, and the expression levels are different. The expression level is closely related to the prognosis of tumors. It is speculated that DSG2 plays different roles in the occurrence and development of different digestive system tumors. This article reviews the biological function of DSG2 and its role in digestive system tumors.

Key words： desmoglein-2 (DSG2); digestive system tumors; biological function

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