上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2022 , Vol. 42 >Issue 10: 1490 - 1497

DOI: https://doi.org/10.3969/j.issn.1674-8115.2022.10.016

综述

嗜黏蛋白阿克曼菌在肠道相关疾病中作用的研究进展

  • 蒋怡 ,
  • 江平 ,
  • 张明明 ,
  • 房静远
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  • 1.上海交通大学医学院附属仁济医院消化科，上海市消化疾病研究所，上海 200001
    2.南京大学医学院附属鼓楼医院消化内科，南京 210093
蒋 怡（1996—），女，硕士生；电子信箱：jiangyi1501@163.com。
房静远，电子信箱：jingyuanfang@sjtu.edu.cn。

收稿日期: 2022-05-07

  录用日期: 2022-08-28

  网络出版日期: 2022-10-17

基金资助

国家自然科学基金(81970487)

收起

Research progress in the role of Akkermansia muciniphila in gut-related diseases

  • Yi JIANG ,
  • Ping JIANG ,
  • Mingming ZHANG ,
  • Jingyuan FANG
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  • 1.Shanghai Institute of Digestive Disease, Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China
    2.Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210093, China
FANG Jingyuan, E-mail: jingyuanfang@sjtu.edu.cn.

Received date: 2022-05-07

  Accepted date: 2022-08-28

  Online published: 2022-10-17

Supported by

National Natural Science Foundation of China(81970487)

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摘要

嗜黏蛋白阿克曼菌（Akkermansia muciniphila，A. muciniphila）是人类肠道中的常见共生菌之一，可利用黏蛋白作为唯一的碳、氮来源，在肠道内定植和生长。肠道稳态对于维持人体正常生理功能至关重要，肠道功能发生紊乱与代谢疾病、免疫疾病、感染性疾病和肿瘤等的发生、发展密切相关。肠道微生物群是影响肠道健康的关键因素，作为肠道微生物的一员，A. muciniphila在肠道炎症、肠道肿瘤、受肠道紊乱影响的疾病（如肝病、代谢性疾病等）中的作用已被证实，且作用机制亦逐渐被阐明，被认为是一种很有前景的候选益生菌。该文针对A. muciniphila的特征、在肠道中的分布、与肠道相关疾病的关联及作用机制进行综述。

关键词： 嗜黏蛋白阿克曼菌; 炎症; 肿瘤; 益生菌; 肠道菌群

本文引用格式

蒋怡 , 江平 , 张明明 , 房静远 . 嗜黏蛋白阿克曼菌在肠道相关疾病中作用的研究进展[J]. 上海交通大学学报（医学版）, 2022 , 42(10) : 1490 -1497 . DOI: 10.3969/j.issn.1674-8115.2022.10.016

Abstract

Akkermansia muciniphila (A. muciniphila) is one of the normal gut symbionts using mucin as the sole source of carbon and nitrogen elements to maintain colonization and growth. Intestinal homeostasis is crucial for maintaining physiological functions. Intestinal dysfunction is closely related to the occurrence and development of metabolic diseases, immune diseases, infectious diseases and tumors. Gut microbiota is a key factor that influences the intestinal health. As a member of the gut microbes, A. muciniphila plays a convincing role in intestinal inflammation, intestinal tumor and other intestinal disorders involving diseases such as liver diseases and metabolic diseases. The mechanism is under exploration and revealed gradually. Hence, A. muciniphila is considered to be a promising candidate of probiotics. The characteristics of A. muciniphila, its distribution in the gut, its relationship with gut-related diseases and the mechanism are reviewed.

Key words： Akkermansia muciniphila (A. muciniphila); inflammation; tumor; probiotics; gut microbiota

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